1(S),9(R)-(−)-Bicuculline methchloride
1(S),9(R)-(−)-Bicuculline methchloride (CAS: 38641-83-7), with the molecular formula C21H21NO6Cl and a molar mass of 417.84 g/mol, is a highly specific GABAA receptor antagonist. Supplied as a powder, this compound is primarily utilized in neuroscience research to investigate neuronal excitability and synaptic transmission. Its role in blocking inhibitory neurotransmission makes it a valuable tool for studying the mechanisms underlying various neurological processes.
- Synonyms
- C21H20NO6Cl1(S),9(R)-(−)-Bicuculline methchloride
Neuroscience Research
1(S),9(R)-(−)-Bicuculline methchloride is used as a pharmacological tool to block GABAA receptors. This allows researchers to study the role of inhibitory neurotransmission in neuronal circuits and brain function.
Investigating Neuronal Excitability
By antagonising GABAergic inhibition, this compound helps in understanding the balance between excitation and inhibition in neural networks. This is crucial for studying conditions related to neuronal hyperexcitability or hypoexcitability.
Synaptic Transmission Studies
Researchers employ bicuculline methchloride to probe the dynamics of synaptic transmission, particularly in understanding the contribution of GABAergic pathways to overall synaptic activity in various brain regions.
| Molecular weight | 417.84 |
|---|---|
| Linear formula | C21H20NO6Cl |
| Assay | ≥97% (HPLC) |
| Form | powder |
| Solubility | H2O: >10 mg/mL |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 1544 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1(S),9(R)-(−)-Bicuculline methchloride used for?
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1(S),9(R)-(−)-Bicuculline methchloride is primarily used as a GABAA receptor antagonist in neuroscience research to investigate neuronal excitability and synaptic transmission.
What are the CAS number and formula for 1(S),9(R)-(−)-Bicuculline methchloride?
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The CAS number for 1(S),9(R)-(−)-Bicuculline methchloride is 38641-83-7, and its linear formula is C21H21NO6Cl.
What grade and purity does Tech Serve Solutions supply for 1(S),9(R)-(−)-Bicuculline methchloride?
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Tech Serve Solutions supplies 1(S),9(R)-(−)-Bicuculline methchloride with an assay of ≥97% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 1(S),9(R)-(−)-Bicuculline methchloride be stored and handled?
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1(S),9(R)-(−)-Bicuculline methchloride should be stored at 2-8°C. Due to its hazardous nature (UN 1544, Hazard Class 6.1), appropriate personal protective equipment including eyeshields, gloves, and a type N95 respirator filter must be used during handling.
Is 1(S),9(R)-(−)-Bicuculline methchloride a controlled substance?
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The provided data does not indicate that 1(S),9(R)-(−)-Bicuculline methchloride is a controlled substance. However, it is classified as hazardous (UN 1544 6.1/PG 3).
How is 1(S),9(R)-(−)-Bicuculline methchloride packed, shipped, and exported?
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Tech Serve Solutions exports fine chemicals, pharmaceutical intermediates, and laboratory reagents globally. Specific packing and shipping details for 1(S),9(R)-(−)-Bicuculline methchloride will be provided upon inquiry, adhering to all relevant transport regulations for hazardous materials.
How can I request a quote or sample for 1(S),9(R)-(−)-Bicuculline methchloride?
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To request a quote or a sample of 1(S),9(R)-(−)-Bicuculline methchloride, please contact our sales department through the TSS website or by telephone. Our team will assist you with your specific requirements.
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