1-(2-Methoxyphenyl)piperazine
1-(2-Methoxyphenyl)piperazine (CAS 35386-24-4) is an ortho-methoxy aryl-substituted piperazine with the molecular formula C11H16N2O and a molar mass of 192.26 g/mol. Supplied at 98% assay, it is a low-melting solid used principally as a heterocyclic building block and pharmaceutical intermediate, and as a reference arylpiperazine ligand in receptor and medicinal-chemistry research. Tech Serve Solutions supplies it as a research/technical grade for synthesis and laboratory use.
- Synonyms
- 1-(2-Methoxyphenyl)piperazine2-Methoxyphenylpiperazineo-Methoxyphenylpiperazine1-(o-Methoxyphenyl)piperazine2-MeOPPCAS 35386-24-4
Pharmaceutical intermediate
Serves as a key arylpiperazine intermediate in the synthesis of active pharmaceutical ingredients and related fine chemicals. The basic secondary-amine nitrogen is readily acylated or alkylated to extend the scaffold.
Heterocyclic building block
A versatile C11 piperazine building block for medicinal and synthetic chemistry. It is commonly used to introduce the 2-methoxyphenylpiperazine motif into larger target molecules.
Receptor and pharmacology research
Used as a reference arylpiperazine in structure-activity and receptor-binding studies, including work on serotonergic (5-HT) and adrenergic targets. Supplied for laboratory research use only.
Reference and analytical standard
Employed as a characterised reference material for method development, identity confirmation and impurity profiling in chemical and pharmaceutical laboratories.
| Molecular weight | 192.26 |
|---|---|
| Empirical formula | C11H16N2O |
| Assay | 98% |
| Boiling point | 130-133 °C/0.1 mmHg(lit.) |
| Density | 1.095 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.575(lit.) |
| Melting point | 35-40 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 3263 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | mouse ... Htr3a(15561)rat ... Adra1a(29412), Drd2(24318), Htr1a(24473), Htr2a(29595), Htr7(65032) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Methoxyphenyl)piperazine used for?
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It is used mainly as a pharmaceutical intermediate and heterocyclic building block, and as a reference arylpiperazine ligand in receptor and medicinal-chemistry research. Its reactive secondary-amine nitrogen makes it a convenient handle for building larger molecules. It is supplied for research and manufacturing use, not for direct human consumption.
What is the CAS number and molecular formula of 1-(2-Methoxyphenyl)piperazine?
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The CAS number is 35386-24-4 and the molecular formula is C11H16N2O, corresponding to a molecular weight of 192.26 g/mol. Related identifiers include MDL number MFCD00005958, EC number 252-537-7 and Beilstein registry number 167888.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(2-Methoxyphenyl)piperazine at a minimum assay of 98% as a research/technical grade for synthesis and laboratory use. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided on request.
What are the safety and handling requirements for 1-(2-Methoxyphenyl)piperazine?
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It is classified GHS05 with the signal word Danger and hazard statement H314 (causes severe skin burns and eye damage). Handle it only with suitable gloves, eye and face protection and respiratory protection where required, avoiding skin and eye contact and dust or vapour inhalation. Always consult the Safety Data Sheet before use.
How is 1-(2-Methoxyphenyl)piperazine packed, shipped and exported?
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It is packed in tightly sealed, suitably labelled containers sized to the order and protected for export. As a corrosive material it is classified for transport under UN 3263, Class 8, Packing Group III, and is shipped in compliance with applicable ADR/IMDG/IATA regulations with full documentation.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will confirm availability, lead time and export terms. Samples and a certificate of analysis can be arranged for evaluation.
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