1-(4-Fluorobenzyl)piperazine
1-(4-Fluorobenzyl)piperazine (CAS 70931-28-1) is a fluorinated piperazine building block with the molecular formula C11H15FN2 and a molar mass of 194.25 g/mol. It pairs a secondary piperazine nitrogen with a 4-fluorobenzyl group, making it a versatile intermediate in chemical synthesis. Tech Serve Solutions supplies it to research and pharmaceutical laboratories as a precursor for a range of biologically active molecules, including chemokine and neurokinin-2 receptor antagonists and kinase inhibitors.
- IUPAC
- 1-[(4-Fluorophenyl)methyl]piperazine
- Synonyms
- 1-(4-Fluorobenzyl)piperazine1-[(4-Fluorophenyl)methyl]piperazine4-Fluorobenzylpiperazine1-(4-Fluorobenzyl)piperazine, CAS 70931-28-1MFCD01075234
Fluorinated piperazine building block
Serves as a heterocyclic, fluorinated building block in chemical synthesis. The free secondary amine on the piperazine ring is a convenient handle for acylation, alkylation and reductive amination to construct more complex scaffolds.
Chemokine and neurokinin receptor antagonists
Used as a precursor in the synthesis of chemokine antagonists and neurokinin-2 (NK2) receptor antagonists. The 4-fluorobenzyl piperazine motif is a recurring fragment in medicinal-chemistry programmes targeting these receptors.
Kinase inhibitor synthesis
Reported as an intermediate in the preparation of EGFR and Aurora A kinase inhibitors. It contributes the fluorobenzyl piperazine unit incorporated into candidate inhibitor structures.
Heterocyclic and antimicrobial scaffolds
Employed in the synthesis of pyrido[1,2-a]benzimidazoles with reported cytotoxic and antiplasmodial activity, and of chlorokojic acid derivatives investigated for antibacterial and antiviral properties.
Cholinesterase and Aβ-aggregation inhibitor research
Applied as a precursor to pyrimidine derivatives studied as cholinesterase and amyloid-beta (Aβ) aggregation inhibitors, supporting neurodegenerative-disease research.
| Molecular weight | 194.25 |
|---|---|
| Empirical formula | C11H15FN2 |
| Application | Precursor involved in the synthesis of a variety of biologically active molecules including:• Chemokine antagonists1• Pyrido[1,2-a]benzimidazoles with cytotoxic and antiplasmodial activity2• Pyrimidine derivatives as cholinesterase and Aβ-aggregation inhibitors3• Chlorokojic acid derivatives with antibacterial and antiviral activities4• EGFR and Aurora A kinase inhibitors5• Neurokinin-2 receptor antagonists6 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Fluorobenzyl)piperazine used for?
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It is mainly used as a fluorinated piperazine building block in chemical synthesis. It is a documented precursor to biologically active molecules including chemokine antagonists, neurokinin-2 receptor antagonists, EGFR and Aurora A kinase inhibitors, pyrido[1,2-a]benzimidazoles, and pyrimidine derivatives studied as cholinesterase and Aβ-aggregation inhibitors.
What is the CAS number and molecular formula of 1-(4-Fluorobenzyl)piperazine?
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The CAS number is 70931-28-1 and the molecular formula is C11H15FN2 (Hill notation). The molecular weight is 194.25 g/mol and the MDL number is MFCD01075234. It is also known as 1-[(4-fluorophenyl)methyl]piperazine.
What grade and purity does Tech Serve Solutions supply?
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We supply 1-(4-Fluorobenzyl)piperazine as a research and technical grade building block for synthesis and laboratory use. We do not represent it as a USP, BP or EP pharmacopoeial grade. A current Certificate of Analysis with batch-specific assay and specifications is provided on request so you can confirm suitability before purchase.
What are the safety and handling requirements?
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It is classified GHS07 with the signal word Warning and hazard statements H302 (harmful if swallowed), H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye and face protection and an N95-type dust mask, avoid dust generation, and consult the Safety Data Sheet before use. It is assigned Water Hazard Class (WGK Germany) 2.
How is 1-(4-Fluorobenzyl)piperazine packed, shipped and exported?
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It is packed in appropriately labelled, tightly sealed containers sized to the order, from laboratory quantities to larger commercial volumes. As a global supplier since 1998, Tech Serve Solutions arranges export shipment with full documentation, including the Safety Data Sheet and Certificate of Analysis, in line with applicable transport and customs requirements for the destination.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and delivery destination, and we will respond with availability, lead time and a quotation. Samples can be discussed for evaluation, subject to availability and applicable regulations.
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