1-(3,4-Dichlorophenyl)biguanide hydrochloride
1-(3,4-Dichlorophenyl)biguanide hydrochloride (CAS 21703-08-2) is an aryl-substituted biguanide salt with the linear formula Cl2C6H3NHC(NH)NHC(NH)NH2 · HCl and a molecular weight of 282.56 g/mol. Supplied as a crystalline organic building block at 97% assay, it serves chiefly as an intermediate and reagent in chemical synthesis, particularly for constructing nitrogen-rich heterocycles such as triazines and related guanidine derivatives. Tech Serve Solutions supplies it to research and industrial users worldwide.
- Synonyms
- 1-(3,4-Dichlorophenyl)biguanide hydrochloride3,4-Dichlorophenylbiguanide hydrochlorideN-(3,4-Dichlorophenyl)imidodicarbonimidic diamide hydrochloride1-(3,4-Dichlorophenyl)-2-biguanide hydrochlorideCl2C6H3NHC(NH)NHC(NH)NH2 · HCl

Synthetic building block
Used as an aryl biguanide intermediate in chemical synthesis, contributing a 3,4-dichlorophenyl-substituted guanidine motif to target molecules. It is a defined organic building block suited to multi-step preparative routes.
Heterocycle formation
Biguanides of this type are classical precursors to 1,3,5-triazine and dihydrotriazine ring systems through condensation chemistry. The compound supports the assembly of nitrogen-rich heterocyclic scaffolds.
Guanidine and nitrogen chemistry
As a member of the guanidine and nitrogen-compound family, it is employed where a strongly basic, chelating biguanide functionality is required. The hydrochloride salt offers a stable, handleable form for laboratory use.
Research and discovery reagent
Applied in academic and industrial research programmes that explore aryl biguanide structure and reactivity. Its well-defined identity makes it suitable for method development and reference work.
| Molecular weight | 282.56 |
|---|---|
| Linear formula | Cl2C6H3NHC(NH)NHC(NH)NH2 · HCl |
| Assay | 97% |
| Melting point | 222-228 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3,4-Dichlorophenyl)biguanide hydrochloride used for?
+
It is used mainly as an organic building block and reagent in chemical synthesis. The aryl biguanide functionality makes it a useful precursor to nitrogen-rich heterocycles such as triazines and to related guanidine derivatives in research and industrial settings.
What is the CAS number and molecular formula of 1-(3,4-Dichlorophenyl)biguanide hydrochloride?
+
Its CAS number is 21703-08-2. The linear formula is Cl2C6H3NHC(NH)NHC(NH)NH2 · HCl (the free base C8H9Cl2N5 as its hydrochloride salt), and the molecular weight is 282.56 g/mol. The MDL number is MFCD00173791.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this material at a typical assay of 97%, as a research and technical-grade organic building block. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch, and the reported melting point is 222-228 °C.
What are the safety and handling requirements?
+
The product carries GHS pictogram GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust generation, and consult the Safety Data Sheet before use.
How is 1-(3,4-Dichlorophenyl)biguanide hydrochloride packed, shipped and exported?
+
It is packed as a solid in suitably sealed containers, with pack sizes from gram quantities to bulk on request. Tech Serve Solutions ships and exports worldwide with full documentation, including a certificate of analysis and Safety Data Sheet, observing applicable transport and import regulations.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time and a quotation. Samples can be arranged for evaluation where appropriate.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis