U-73343
U-73343 (CAS: 142878-12-4), with the molecular formula C29H42N2O3 and a molecular weight of 466.66, is a research chemical primarily used in cell biology and neuroscience studies. It acts as an inhibitor of phospholipase C (PLC) signaling pathways. This compound is valuable for investigating the role of PLC in cellular processes, including its modulation of ion channel function, and serves as a useful negative control in relevant experimental setups.
- IUPAC
- 1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione
Phospholipase C (PLC) Signaling Research
U-73343 is employed to study the specific roles and mechanisms of phospholipase C (PLC) signaling pathways in cellular functions. Its inhibitory action allows researchers to dissect the downstream effects of PLC activation or inactivation in various biological contexts.
Modulation of Epithelial Sodium Channel (ENaC) Function
This compound has been utilised to investigate the influence of PLC signaling on the function of the epithelial sodium channel (ENaC). Research using U-73343 helps elucidate the complex interplay between lipid signaling and ion transport in epithelial tissues.
Cellular Mechanotransduction Studies
U-73343 serves as a tool in studies examining how cells respond to mechanical stimuli. By inhibiting PLC, researchers can explore the signalling cascades that link mechanical stress to cellular responses, particularly in contexts involving adjacent cell signalling.
Negative Control in Phospholipid Metabolism Research
The compound is also applied as a negative control in experiments investigating phospholipid metabolism and signaling. Its use helps to validate findings related to other inhibitors or activators within these pathways.
| Molecular weight | 466.66 |
|---|---|
| Empirical formula | C29H42N2O3 |
| Assay | ≥90% |
| Form | powder |
| Colour | white |
| Solubility | ethanol: soluble0.93 mg/mLchloroform: soluble10 mg/mL, clear, colorless to faintly yellowDMSO: soluble2.3 mg/mLH2O: insoluble |
| Application | U-73343 has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs)1. U-73343 has also been used as a negative control for PLC inhibition in mechanically stimulated (MS) and its neighboring (NB) cells2. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is U-73343 used for?
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U-73343 is used for studying the role of phospholipase C (PLC) signaling in cellular functions, including its modulation of epithelial Na+ channel (ENaC) function, and as a negative control in various cellular signaling and phospholipid metabolism research.
What is the CAS number and empirical formula for U-73343?
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The CAS number for U-73343 is 142878-12-4, and its empirical formula is C29H42N2O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies U-73343 with a purity of ≥90%. This product is intended for laboratory research purposes and is not supplied as USP, BP, EP, or any other pharmacopoeial grade.
How should U-73343 be handled safely?
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U-73343 is a Warning substance (GHS07) that may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, in a well-ventilated area. Avoid breathing dust.
How is U-73343 packed and exported?
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U-73343 is typically supplied as a white powder. Tech Serve Solutions specialises in the global supply and export of fine chemicals and laboratory reagents, adhering to international shipping regulations.
How can I request a sample or quote for U-73343?
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To request a sample or a quotation for U-73343, please contact our sales department through the website or by phone, providing your specific requirements and shipping details.
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