U 18666A
U 18666A hydrochloride (CAS: 3039-71-2), with the empirical formula C25H41NO2·HCl and a molecular weight of 424.06 g/mol, is a research chemical supplied by Tech Serve Solutions. It is primarily utilised in cell biology and cholesterol metabolism studies. This compound has demonstrated utility in investigating cellular processes, particularly in understanding mechanisms related to autophagy in Niemann-Pick Disease Type C (NPC) cells.
- IUPAC
- (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
- Synonyms
- (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride

Autophagy Studies in Niemann-Pick Disease
U 18666A has been employed in experimental setups using fibroblast controls to investigate the mechanisms by which autophagy is increased in Niemann-Pick Disease Type C (NPC) cells. This application aids in understanding disease progression and potential therapeutic targets.
Cellular Cholesterol Metabolism Research
As a compound related to cholesterol metabolism, U 18666A is valuable for researchers studying lipid dynamics within cells. Its use can help elucidate pathways involved in cellular lipid regulation and transport.
Cell Signaling Investigations
This chemical serves as a tool in cell signaling research, particularly within neuroscience contexts. It allows scientists to explore signaling pathways influenced by lipids and cholesterol.
| Molecular weight | 424.06 |
|---|---|
| Empirical formula | C25H41NO2·HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | H2O: soluble10 mg/mL≥ |
| Storage temperature | 2-8°C |
| Melting point | 195-196.5 °C(lit.) |
| Application | U 18666A has been used in fibroblast controls to study the mechanism of increase in autophagy in Niemann-Pick Disease Type C (NPC) cells1. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is U 18666A used for?
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U 18666A is used in research for studying mechanisms of autophagy increase in Niemann-Pick Disease Type C cells, investigating cellular cholesterol metabolism, and exploring cell signaling pathways, particularly in neuroscience.
What is the CAS number and chemical formula for U 18666A?
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The CAS number for U 18666A is 3039-71-2, and its chemical formula is C25H41NO2·HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies U 18666A with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should U 18666A be handled?
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Handling U 18666A requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if necessary. It is classified under WGK Germany 3, indicating a high hazard level.
How is U 18666A shipped and exported?
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Tech Serve Solutions, a global supplier and exporter, can arrange for the packing, shipping, and export of U 18666A to qualified research institutions worldwide, adhering to all relevant regulations.
How can I request a sample or quote for U 18666A?
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To request a sample or quote for U 18666A, please contact our sales department through the TSS website or by phone.
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