Tyrphostin AG 879
Tyrphostin AG 879 (CAS: 148741-30-4, Formula: C18H24N2OS, MW: 316.46) is a potent inhibitor of receptor tyrosine kinases. Primarily used in research settings, it is recognised for its role in investigating cellular signalling pathways, particularly in cancer research and cell biology. Its ability to modulate ErbB2 receptor phosphorylation and function as a neurotrophic tyrosine kinase receptor inhibitor makes it a valuable tool for studying complex biological processes.
- IUPAC
- α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
ErbB2 Receptor Phosphorylation Studies
Tyrphostin AG 879 has been employed to investigate the phosphorylation of the ErbB2 receptor in A431 cells, demonstrating significant inhibitory effects at specific concentrations.
Neurotrophic Tyrosine Kinase Receptor Inhibition
This compound serves as a tool for researchers studying the role of neurotrophic tyrosine kinase receptors, for example, in the disruption of Sertoli cell aggregation.
Antitumor Agent Research
As an agent with antitumor properties, Tyrphostin AG 879 is utilised in preclinical research to explore novel therapeutic strategies against cancer.
Cellular Signalling Pathway Investigation
Its mechanism of action as a kinase inhibitor makes it useful for dissecting complex cellular signalling cascades relevant to cell biology and neuroscience.
| Molecular weight | 316.46 |
|---|---|
| Empirical formula | C18H24N2OS |
| Assay | 99% (HPLC) |
| Solubility | DMSO: soluble (at 26 mg/ml)H2O: insoluble |
| Application | Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation1. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation2. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ERBB2(2064), NTRK1(4914) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tyrphostin AG 879 used for?
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Tyrphostin AG 879 is used in scientific research for its properties as a receptor tyrosine kinase inhibitor, particularly in studies involving ErbB2 receptor phosphorylation, neurotrophic tyrosine kinase receptor signalling, and as a tool in antitumor and cell biology research.
What is the CAS number and formula for Tyrphostin AG 879?
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The CAS number for Tyrphostin AG 879 is 148741-30-4, and its empirical formula is C18H24N2OS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tyrphostin AG 879 with a purity of 99% (HPLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
What are the safety and handling requirements for Tyrphostin AG 879?
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When handling Tyrphostin AG 879, appropriate personal protective equipment including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter is required. The substance has a WGK Germany rating of 3.
How is Tyrphostin AG 879 shipped or exported?
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Tech Serve Solutions reliably packs, ships, and exports Tyrphostin AG 879 globally, adhering to all necessary regulations for chemical transport.
How can I request a sample or quote for Tyrphostin AG 879?
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To request a sample or a quotation for Tyrphostin AG 879, please contact our sales team via the website or by phone.
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