Tris(4-fluorophenyl)phosphine
Tris(4-fluorophenyl)phosphine (CAS 18437-78-0), with the linear formula (FC₆H₄)₃P and a molecular weight of 316.26 g/mol, is a white to off-white crystalline solid. It is primarily utilised as a ligand in catalysis and as a key intermediate in chemical synthesis, particularly within organophosphorus chemistry. This compound offers specific electronic and steric properties valuable for various catalytic applications, contributing to efficient chemical transformations.
- IUPAC
- Tri-(p-fluorophenyl)phosphine
- Synonyms
- Tri-(p-fluorophenyl)phosphine

Catalysis
Tris(4-fluorophenyl)phosphine serves as a valuable phosphine ligand in homogeneous catalysis. Its electron-withdrawing fluoro substituents modify the electronic properties of the metal center, influencing catalytic activity and selectivity in reactions such as cross-couplings.
Chemical Synthesis
This compound is employed as a building block or reagent in the synthesis of more complex organophosphorus compounds. Its defined structure makes it useful for constructing molecules with specific electronic and steric requirements.
Research and Development
Used in academic and industrial research settings to explore new catalytic systems, reaction mechanisms, and the development of novel materials with tailored properties.
| Molecular weight | 316.26 |
|---|---|
| Linear formula | (FC6H4)3P |
| Assay | 98% |
| Melting point | 79-83 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Greener Alternative Product Characteristics | Catalysis |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tris(4-fluorophenyl)phosphine used for?
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Tris(4-fluorophenyl)phosphine is primarily used as a ligand in catalysis, particularly in cross-coupling reactions, and as an intermediate in chemical synthesis, especially for organophosphorus compounds.
What is the CAS number and formula for Tris(4-fluorophenyl)phosphine?
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The CAS number is 18437-78-0 and its linear formula is (FC₆H₄)₃P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tris(4-fluorophenyl)phosphine with an assay of 98%. This product is intended for research and chemical synthesis applications and is not supplied as USP, BP, EP, or pharmaceutical grade.
How should Tris(4-fluorophenyl)phosphine be handled safely?
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Tris(4-fluorophenyl)phosphine is a Warning substance (GHS07) that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust.
How is Tris(4-fluorophenyl)phosphine packed and shipped?
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Tris(4-fluorophenyl)phosphine is carefully packed to ensure safe transit. Tech Serve Solutions is a global supplier and exporter, adhering to international shipping regulations for chemical products.
How can I request a sample or quote for Tris(4-fluorophenyl)phosphine?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team through the website or by phone, providing the product name and CAS number (18437-78-0).
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