Methyl trifluoroacetate
Methyl trifluoroacetate (CAS 431-47-0), with the molecular formula C3H3F3O2 and a molar mass of 128.05 g/mol, is a versatile organic ester. It is recognised for its utility as a reagent in chemical synthesis, specifically for the trifluoroacetylation of amines and amino acids. This compound serves as a valuable building block in various organic chemistry applications.
Trifluoroacetylation Reagent
Methyl trifluoroacetate is effectively employed as a reagent for the trifluoroacetylation of primary and secondary amines. This process is crucial for introducing the trifluoroacetyl group, a common motif in pharmaceuticals and agrochemicals.
Amino Acid Derivatisation
This ester serves as a reagent for the derivatisation of amino acids, facilitating their analysis or modification. The trifluoroacetyl group can alter the properties of amino acids for chromatographic or spectroscopic studies.
Organic Synthesis Building Block
As a fluorinated ester, methyl trifluoroacetate acts as a useful building block in organic synthesis. Its reactivity allows for incorporation into more complex molecules, contributing unique fluorinated functionalities.
| Molecular weight | 128.05 |
|---|---|
| Linear formula | CF3COOCH3 |
| Assay | 99% |
| Boiling point | 43-43.5 °C(lit.) |
| Density | 1.273 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.291(lit.) |
| Vapour pressure | 5.77 psi (20 °C) |
| Application | Methyl trifluoroacetate has been used as reagent for trifluoroacetylation of amines and amino acids. |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | -20 °C / -4 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl trifluoroacetate used for?
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Methyl trifluoroacetate (CAS 431-47-0) is primarily used as a reagent for the trifluoroacetylation of amines and amino acids in chemical synthesis.
What is the CAS number and formula for Methyl trifluoroacetate?
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The CAS number for Methyl trifluoroacetate is 431-47-0 and its linear formula is CF3COOCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl trifluoroacetate with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should Methyl trifluoroacetate be handled safely?
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Methyl trifluoroacetate is a flammable liquid and causes severe skin burns and eye damage (H225-H314). Handle with appropriate personal protective equipment, including gloves, goggles, and respiratory protection, in a well-ventilated area, and keep away from ignition sources.
How is Methyl trifluoroacetate shipped and exported?
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Methyl trifluoroacetate is shipped and exported under UN 2924, Hazard Class 8 (3), Packing Group II, indicating it is a corrosive liquid, flammable, having a subsidiary risk.
How can I request a quote or sample?
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To request a quote or sample of Methyl trifluoroacetate, please contact our sales team through our website or by phone.
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