Methyl trimethylsilylacetate
Methyl trimethylsilylacetate (CAS 2916-76-9) is a liquid organic compound with the molecular formula (CH3)3SiCH2CO2CH3 and a molecular weight of 146.26 g/mol. It is valuable as a building block and reagent in chemical synthesis. Its properties make it useful in reactions involving carbonyl compounds and esters. Tech Serve Solutions supplies this compound for various research and development applications.

Organic Synthesis Intermediate
Methyl trimethylsilylacetate serves as a versatile intermediate in organic synthesis. It is employed in the construction of more complex molecular architectures, particularly those involving ester and carbonyl functionalities.
Reagent in Silane Chemistry
This compound finds application as a reagent in silane chemistry, facilitating the introduction of silyl groups or acting as a precursor in reactions requiring organosilicon compounds.
Building Block for Specialty Chemicals
Utilized as a fundamental building block, it contributes to the synthesis of specialty chemicals and advanced materials. Its structure allows for specific chemical transformations.
| Molecular weight | 146.26 |
|---|---|
| Linear formula | (CH3)3SiCH2CO2CH3 |
| Assay | 97% |
| Boiling point | 38-39 °C/13 mmHg(lit.) |
| Density | 0.891 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.414(lit.) |


Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 33 °C / 91.4 °F |
| Transport (UN / ADR) | UN 3272 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl trimethylsilylacetate used for?
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Methyl trimethylsilylacetate is primarily used as a building block and reagent in organic synthesis, particularly in reactions involving carbonyl compounds and esters, and in silane chemistry.
What is the CAS number and formula for Methyl trimethylsilylacetate?
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The CAS number for Methyl trimethylsilylacetate is 2916-76-9 and its linear formula is (CH3)3SiCH2CO2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl trimethylsilylacetate with an assay of 97%. This is a technical/research grade, and TSS does not represent it as USP, BP, or EP grade.
How should Methyl trimethylsilylacetate be handled safely?
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Methyl trimethylsilylacetate is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and use in a well-ventilated area. Ensure appropriate respiratory protection is used.
How is Methyl trimethylsilylacetate packed and shipped?
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Methyl trimethylsilylacetate is shipped as a flammable liquid, UN 3272, Class 3, Packing Group III. Packaging adheres to international shipping regulations for hazardous materials.
How can I request a sample or quote for Methyl trimethylsilylacetate?
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To request a sample or a quote for Methyl trimethylsilylacetate, please contact the Tech Serve Solutions sales team through our website or by phone.
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