Trimethylsilyl trifluoroacetate

CAS 400-53-3CF3CO2Si(CH3)3Chemical Synthesis

Trimethylsilyl trifluoroacetate (CAS 400-53-3), with the chemical formula CF3CO2Si(CH3)3 and a molecular weight of 186.20 g/mol, is a valuable reagent in organic synthesis. It serves as a trifluoroacetylating agent and a silylating agent, facilitating the protection of functional groups and the introduction of the trifluoroacetyl moiety in complex molecule construction. Its utility spans various chemical research and development applications.

IUPAC: Trifluoroacetic acid trimethylsilyl ester

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Trimethylsilyl trifluoroacetate (CF3CO2Si(CH3)3) — chemical structure, CAS 400-53-3; Chemistry, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Trifluoroacetylation Reagent

Trimethylsilyl trifluoroacetate is employed to introduce the trifluoroacetyl group into organic molecules. This functionalization is important in modifying the properties of compounds or as an intermediate step in further synthetic transformations.

Silylating Agent

The compound can act as a silylating agent, particularly for the protection of hydroxyl or amine functionalities. This is a common strategy in multi-step organic syntheses to temporarily mask reactive groups.

Building Block in Organic Synthesis

As an ester and a silicon-containing compound, it functions as a versatile building block. It is useful in the preparation of more complex molecules within pharmaceutical and fine chemical research.

02 /Properties

Molecular weight	186.20
Linear formula	CF3CO2Si(CH3)3
Assay	≥97.0% (T)
Boiling point	88-90 °C(lit.)
Density	1.078 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.336(lit.)n20/D 1.336
Vapour density	>1 (vs air)

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H225Highly flammable liquid and vapour
H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat, sparks and open flames. No smoking
P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	13 °C / 55.4 °F
Transport (UN / ADR)	UN 2924 8(3) / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	F,C
Risk statements (R)	11-34-37
Safety statements (S)	16-26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

400-53-3

MDL number

MFCD00000413

Beilstein registry

1773314

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Trimethylsilyl trifluoroacetate used for?

Trimethylsilyl trifluoroacetate is primarily used as a trifluoroacetylating and silylating agent in organic synthesis for introducing the trifluoroacetyl group or protecting functional groups.

What are the CAS number and formula for Trimethylsilyl trifluoroacetate?

The CAS number is 400-53-3 and the chemical formula is CF3CO2Si(CH3)3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Trimethylsilyl trifluoroacetate with an assay of ≥97.0% (T). TSS does not represent this product as USP, BP, or EP grade.

What are the main hazards associated with Trimethylsilyl trifluoroacetate?

Trimethylsilyl trifluoroacetate is a flammable liquid and causes severe skin burns and eye damage (H225, H314). It requires careful handling with appropriate personal protective equipment.

How is Trimethylsilyl trifluoroacetate packed, shipped, and exported?

We offer various packaging options suitable for its properties, adhering to international shipping regulations. TSS is a global supplier and exporter experienced in handling such chemicals.

How can I request a sample or quote for Trimethylsilyl trifluoroacetate?

To request a sample or a quote, please use the 'Request a Quote' or 'Sample Request' form available on our website, or contact our sales team directly.