Trimethylsilyl cyanide
Trimethylsilyl cyanide (CAS 7677-24-9) is a colourless liquid with the molecular formula (CH3)3SiCN and a molecular weight of 99.21 g/mol. This versatile organosilicon compound is a crucial reagent in organic synthesis, particularly for introducing the cyano group. Its controlled reactivity makes it valuable in the preparation of various complex organic molecules. Supplied by TSS, it is available in technical grade with a minimum assay of 98%.
- IUPAC
- Cyanotrimethylsilane,TMSCN
- Synonyms
- CyanotrimethylsilaneTMSCN
Cyanosilylation Reactions
Trimethylsilyl cyanide is extensively used in cyanosilylation reactions, serving as a source of the cyanide nucleophile for addition to carbonyl compounds and imines, facilitating the synthesis of cyanohydrins and related derivatives.
Organic Synthesis Building Block
It acts as a versatile building block in organic synthesis, enabling the introduction of nitrile functionalities into diverse molecular structures, which can be further transformed into other functional groups like amines and carboxylic acids.
Pharmaceutical Intermediate Synthesis
This reagent finds application in the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex organic molecules, where precise introduction of a nitrile group is required.
| Molecular weight | 99.21 |
|---|---|
| Linear formula | (CH3)3SiCN |
| Assay | 98% |
| Grade | technical |
| Boiling point | 114-117 °C(lit.) |
| Density | 0.793 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.392(lit.) |
| Melting point | 8-11 °C(lit.) |
Hazard statements
- H225Highly flammable liquid and vapour
- H300Fatal if swallowed
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 1 °C / 33.8 °F |
| Transport (UN / ADR) | UN 3384 3(6.1) / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,T+ |
| Risk statements (R) | 11-26/27/28-29 |
| Safety statements (S) | 16-36/37/39-45 |
| Supplemental hazards | Contact with water liberates toxic gas. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethylsilyl cyanide used for?
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Trimethylsilyl cyanide (CAS 7677-24-9) is primarily used in organic synthesis for cyanosilylation reactions and as a building block to introduce nitrile groups into molecules. It is valuable in the synthesis of pharmaceuticals and other complex organic compounds.
What are the CAS number and formula for Trimethylsilyl cyanide?
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The CAS number for Trimethylsilyl cyanide is 7677-24-9, and its linear formula is (CH3)3SiCN.
What grade and purity does Tech Serve Solutions supply for Trimethylsilyl cyanide?
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Tech Serve Solutions supplies Trimethylsilyl cyanide in a technical grade with a minimum assay of 98%. TSS does not represent this product as USP, BP, or EP grade.
How should Trimethylsilyl cyanide be handled safely?
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Trimethylsilyl cyanide is a highly hazardous substance (Danger, H225, H300 + H310 + H330) that is flammable and acutely toxic by inhalation, skin contact, and ingestion. Contact with water liberates toxic gas. Handle with extreme caution in a well-ventilated area, wearing appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Refer to the Safety Data Sheet for comprehensive handling instructions.
Is Trimethylsilyl cyanide a controlled substance?
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Based on the provided data, there is no indication that Trimethylsilyl cyanide is a controlled substance. However, regulations can vary by jurisdiction, and end-users should verify local requirements.
How is Trimethylsilyl cyanide packed, shipped, and exported?
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Trimethylsilyl cyanide is packed and shipped according to international regulations for hazardous materials. TSS can export this chemical globally to qualified customers, adhering to all necessary shipping and customs protocols.
How can I request a quote or sample for Trimethylsilyl cyanide?
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To request a quote or a sample of Trimethylsilyl cyanide, please contact the TSS sales team through our website or by phone. Provide your contact details and the quantity required.
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