Trimethylsilyl bromoacetate
Trimethylsilyl bromoacetate (CAS: 18291-80-0), with the linear formula BrCH₂CO₂Si(CH₃)₃, is a valuable organic compound with a molecular weight of 211.13 g/mol. This ester serves as a versatile building block in chemical synthesis. It is particularly useful as an alkylating agent and in the preparation of complex organic molecules, including pharmaceuticals and natural products. Its reactivity makes it a key intermediate for creating specialized functional groups and molecular architectures.
Preparation of Imidazolium Salts
Trimethylsilyl bromoacetate is employed in synthesising novel imidazolium salts. These salts are functionalised with a trimethylsilyl ester group, offering unique properties for various chemical applications.
Synthesis of Natural Products
This compound acts as an alkylating agent in the synthesis of crucial fragments for natural products, such as the succinate moiety in the antibiotic pantocin B.
Development of Pharmaceutical Derivatives
It is utilised in the intricate synthesis pathways for developing complex pharmaceutical derivatives, including specific taxol analogues tethered to biologically relevant molecules like glutamate and folate.
| Molecular weight | 211.13 |
|---|---|
| Linear formula | BrCH2CO2Si(CH3)3 |
| Assay | 98% |
| Boiling point | 57-58 °C/9 mmHg(lit.) |
| Density | 1.284 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.442(lit.) |
| Vapour density | >1 (vs air) |
| Application | Trimethylsilyl bromoacetate has been used:• in the preparation of new imidazolium salts functionalized with the trimethylsilyl ester group1• as alkylating agent in the synthesis of succinate fragment of pantocin B (antibiotic natural product)2• in the synthesis of taxol derivatives tethered at C2′ and C-7 to glutamate and folate3 |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 47 °C / 116.6 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethylsilyl bromoacetate used for?
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Trimethylsilyl bromoacetate is used in organic synthesis as an alkylating agent and for preparing functionalised imidazolium salts and complex pharmaceutical derivatives.
What is the CAS number and formula for Trimethylsilyl bromoacetate?
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The CAS number is 18291-80-0, and the linear formula is BrCH₂CO₂Si(CH₃)₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trimethylsilyl bromoacetate with an assay of 98%. This product is suitable for research and general chemical synthesis; TSS does not represent it as USP, BP, or EP grade.
How should Trimethylsilyl bromoacetate be handled safely?
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Trimethylsilyl bromoacetate is a dangerous substance (Danger) that causes severe skin burns and eye damage (H314) and is a flammable liquid and vapour (H226). Handle with extreme care using appropriate personal protective equipment, including face shields, gloves, goggles, and suitable respiratory protection, in a well-ventilated area.
Is Trimethylsilyl bromoacetate a controlled substance?
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The provided data does not indicate that Trimethylsilyl bromoacetate is a controlled substance.
How are your chemicals packed, shipped, and exported?
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Products are packed securely according to international shipping regulations for hazardous materials. We offer global export services for research and industrial clients.
How can I request a quote or sample?
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Please contact our sales team via the website or direct email to request a quote or a sample of Trimethylsilyl bromoacetate.
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