Trimethylsilyl acetate
Trimethylsilyl acetate (CAS: 2754-27-0), with the chemical formula CH3CO2Si(CH3)3 and a molecular weight of 132.23 g/mol, is a versatile organosilicon compound. It functions primarily as a protecting group and a reagent in organic synthesis. Its properties make it valuable for acyl group transfer and in the preparation of silyl enol ethers, finding utility in various chemical research and development applications.
Protecting Group Chemistry
Trimethylsilyl acetate serves as an effective acetylating agent, enabling the temporary protection of hydroxyl and amino groups during complex organic syntheses. This protection facilitates selective reactions on other parts of a molecule.
Acyl Group Transfer Reagent
It is employed as a reagent for the transfer of the acetyl group, particularly in the synthesis of esters and amides. This reaction is crucial in the construction of various organic molecules.
Synthesis of Silyl Enol Ethers
Trimethylsilyl acetate is a precursor for the formation of silyl enol ethers from carbonyl compounds. These intermediates are vital in carbon-carbon bond-forming reactions, such as aldol reactions and alkylations.
Research and Development
This compound is a fundamental building block used in academic and industrial research laboratories for exploring new synthetic methodologies and developing novel chemical entities.
| Molecular weight | 132.23 |
|---|---|
| Linear formula | CH3CO2Si(CH3)3 |
| Assay | 97% |
| Boiling point | 107.5 °C(lit.) |
| Density | 0.882 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.388(lit.) |
| Vapour pressure | 35 mmHg (30 °C) |
| Melting point | −32 °C(lit.) |
| Vapour density | 1 (vs air) |
Hazard statements
- H225Highly flammable liquid and vapour
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 19 °C / 66.2 °F |
| Transport (UN / ADR) | UN 3272 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
| Safety statements (S) | 16-23 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethylsilyl acetate used for?
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Trimethylsilyl acetate is primarily used as an acetylating agent and a protecting group in organic synthesis, and for the preparation of silyl enol ethers.
What is the CAS number and chemical formula for Trimethylsilyl acetate?
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The CAS number is 2754-27-0 and the chemical formula is CH3CO2Si(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trimethylsilyl acetate with a minimum assay of 97%. This product is intended for laboratory and research purposes and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should Trimethylsilyl acetate be handled safely?
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Trimethylsilyl acetate is a highly flammable liquid and vapour (H225). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure adequate ventilation and keep away from heat, sparks, and open flames.
How is Trimethylsilyl acetate packed, shipped, and exported?
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As a specialist global supplier, Tech Serve Solutions expertly packs and ships chemicals according to international regulations. For specific packaging and export details, please contact our sales team.
How can I request a sample or a quote for Trimethylsilyl acetate?
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To request a sample or a quote, please contact our dedicated sales department via the website or direct email, providing your specific requirements.
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