Trimethylsilyl trichloroacetate
Trimethylsilyl trichloroacetate (CAS 25436-07-1), with the chemical formula CCl3CO2Si(CH3)3 and a molecular weight of 235.57 g/mol, is a versatile organic compound. It serves as a valuable building block and reagent in chemical synthesis, particularly within the realm of carbonyl compounds and ester chemistry. Its distinct properties make it suitable for various research and development applications.

Organic Synthesis Reagent
Trimethylsilyl trichloroacetate is employed as a reagent in organic synthesis for the introduction of specific functional groups. Its utility extends to the preparation of various organic intermediates and complex molecules.
Ester Chemistry
This compound is utilized in reactions involving ester formation and modification. It can act as a precursor or reagent in processes that manipulate ester functionalities.
Carbonyl Compound Derivatization
It finds application in the derivatization of carbonyl compounds, offering a route to modify or protect these functional groups during multi-step syntheses.
Research and Development
As a fine chemical, Trimethylsilyl trichloroacetate is a key component in R&D laboratories, supporting the exploration of new chemical pathways and material development.
| Molecular weight | 235.57 |
|---|---|
| Linear formula | CCl3CO2Si(CH3)3 |
| Assay | 98% |
| Boiling point | 70-73 °C/12 mmHg(lit.) |
| Density | 1.245 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.44(lit.) |


Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 38 °C / 100.4 °F |
| Transport (UN / ADR) | UN 3272 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethylsilyl trichloroacetate used for?
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Trimethylsilyl trichloroacetate is used as a reagent in organic synthesis, particularly in ester chemistry and the derivatization of carbonyl compounds. It is a valuable building block for chemical research and development.
What is the CAS number and formula for Trimethylsilyl trichloroacetate?
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The CAS number for Trimethylsilyl trichloroacetate is 25436-07-1, and its chemical formula is CCl3CO2Si(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trimethylsilyl trichloroacetate with a purity of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Trimethylsilyl trichloroacetate be handled safely?
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Trimethylsilyl trichloroacetate is a flammable liquid and vapour (H226), and is harmful if swallowed (H302), in contact with skin (H312), or if inhaled (H332). It also causes skin irritation (H315) and serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and suitable respiratory protection, must be used. Handle in a well-ventilated area away from ignition sources.
How is Trimethylsilyl trichloroacetate packed, shipped, and exported?
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Trimethylsilyl trichloroacetate is carefully packed according to international shipping regulations. As a global supplier, Tech Serve Solutions exports this chemical worldwide, adhering to all relevant transport and customs requirements.
How can I request a sample or quote for Trimethylsilyl trichloroacetate?
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To request a sample or a quote for Trimethylsilyl trichloroacetate, please contact our sales team through the website or by calling our main office. Please specify the quantity required.
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