Trifluoroacetic anhydride
Trifluoroacetic anhydride (CAS: 407-25-0) is a powerful dehydrating and acylating agent. With the linear formula (CF3CO)2O and a molecular weight of 210.03 g/mol, this compound is a colourless liquid with a pungent odour. It is highly reactive, particularly with water, and is widely employed in organic synthesis for trifluoroacetylation reactions, acting as a strong catalyst, and in the preparation of various organic compounds.
- IUPAC
- TFAA
- Synonyms
- Trifluoroacetic acid anhydrideTrifluoroacetic acid 2,2,2-trifluoroethyl esterTFAA
Trifluoroacetylation Reagent
Trifluoroacetic anhydride is a primary reagent for introducing the trifluoroacetyl group (CF3CO-) into organic molecules. This is crucial in pharmaceuticals and agrochemicals for modifying molecular properties.
Dehydrating Agent
Its strong affinity for water makes TFAA an effective dehydrating agent in various chemical reactions, facilitating condensation and esterification processes where water removal is critical.
Catalyst in Organic Synthesis
It serves as a potent Lewis acid catalyst in numerous organic transformations, including Friedel-Crafts acylations and cyclisation reactions, accelerating reaction rates and improving yields.
Peptide Synthesis
Used in the synthesis of peptides for the protection of amino groups or as a reagent in specific coupling strategies within complex peptide chains.
| Molecular weight | 210.03 |
|---|---|
| Linear formula | (CF3CO)2O |
| Boiling point | 39.5-40 °C(lit.) |
| Density | 1.511 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.3(lit.) |
| Vapour pressure | 6.28 psi (20 °C) |
| Melting point | −65 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGI |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-20-35-52/53 |
| Safety statements (S) | 26-36/37/39-43-45-61 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trifluoroacetic anhydride used for?
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Trifluoroacetic anhydride is primarily used as a trifluoroacetylation reagent, a dehydrating agent, and a catalyst in various organic synthesis applications, including peptide synthesis.
What is the CAS number and formula for Trifluoroacetic anhydride?
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The CAS number for Trifluoroacetic anhydride is 407-25-0, and its linear formula is (CF3CO)2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trifluoroacetic anhydride with a purity typically at or above 99%. Please refer to the specific Certificate of Analysis for lot-specific details. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Trifluoroacetic anhydride be handled safely?
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Trifluoroacetic anhydride is a dangerous substance. It reacts violently with water and causes severe skin burns and eye damage (H314). It is also harmful if inhaled (H332). Always use appropriate personal protective equipment, including face shields, gloves, and respirators, and handle in a well-ventilated area or fume hood. Refer to the Safety Data Sheet for comprehensive handling instructions.
How is Trifluoroacetic anhydride packed and shipped?
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Trifluoroacetic anhydride is typically packed in UN-approved containers suitable for corrosive liquids. It is shipped in compliance with international regulations for hazardous materials. As a global supplier, TSS handles export requirements for this product.
How can I request a quote or sample?
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To request a quote or sample of Trifluoroacetic anhydride, please use the 'Request a Quote' or 'Request a Sample' function on our website, providing your contact details and required quantity.
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