Trifluoroacetaldehyde ethyl hemiacetal
Trifluoroacetaldehyde ethyl hemiacetal (CAS: 433-27-2), with the molecular formula CF3CH(OH)OCH2CH3 and a molecular weight of 144.09 g/mol, serves as a stable alternative to gaseous trifluoroacetaldehyde. This organic compound is predominantly employed in organic synthesis as a valuable building block for creating α-trifluoromethylated alcohols. These derivatives find applications in the development of pharmaceuticals, including antifungals, antitumor agents, and other chemotherapeutic compounds.
- IUPAC
- 1-Ethoxy-2,2,2-trifluoroethanol
- Synonyms
- 1-Ethoxy-2,2,2-trifluoroethanol
Pharmaceutical Intermediate Synthesis
Utilised as a key building block for synthesising α-trifluoromethylated alcohols, which are crucial intermediates in the development of various pharmaceutical agents such as antifungals and antitumor drugs.
Organic Synthesis
Serves as a convenient and stable source of the trifluoroacetaldehyde moiety in organic reactions, enabling the introduction of trifluoromethyl groups into complex molecules.
Research and Development
An essential reagent in academic and industrial research laboratories for exploring novel synthetic pathways and developing new chemical entities with potential therapeutic benefits.
| Molecular weight | 144.09 |
|---|---|
| Linear formula | CF3CH(OH)OCH2CH3 |
| Assay | 90% |
| Boiling point | 104-105 °C/745 mmHg(lit.) |
| Density | 1.221 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.342(lit.) |
| Storage temperature | 2-8°C |
| Impurities tested | ≤12% water |
| Application | Alternative to gaseous unstable trifluoroacetaldehyde: used to prepare α-trifluoromethylated alcohols for antifungals, antitumor, and chemotherapeutic agents.1,2,3 |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 39 °C / 102.2 °F |
| Transport (UN / ADR) | UN 1989C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-22 |
| Safety statements (S) | 16 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trifluoroacetaldehyde ethyl hemiacetal used for?
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Trifluoroacetaldehyde ethyl hemiacetal is primarily used as a stable alternative to gaseous trifluoroacetaldehyde for synthesising α-trifluoromethylated alcohols, which are important intermediates for antifungals, antitumor agents, and chemotherapeutic compounds.
What are the CAS number and chemical formula?
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The CAS number is 433-27-2 and the chemical formula is CF3CH(OH)OCH2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trifluoroacetaldehyde ethyl hemiacetal with an assay of 90%, containing no more than 12% water. This product is supplied for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
What are the main safety hazards associated with this chemical?
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This compound is a flammable liquid and vapour (H226), is harmful if swallowed (H302), and causes serious eye irritation (H319). Always handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area.
How is Trifluoroacetaldehyde ethyl hemiacetal stored and shipped?
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It should be stored at 2-8°C. As a flammable liquid (UN 1989, Class 3, Packing Group III), it is exported and shipped in compliance with international regulations for hazardous materials.
How can I request a sample or quote?
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To request a sample or a quotation, please contact the TSS sales team through our website or by direct inquiry, providing your specific requirements and shipping details.
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