Trifluoroacetyl chloride
Trifluoroacetyl chloride (CAS: 354-32-5, CF3COCl) is a potent acylating agent with a molecular weight of 132.47 g/mol. Characterised by its highly reactive nature, this compound is primarily employed in organic synthesis for the introduction of the trifluoroacetyl group. Its utility spans various chemical processes, making it a valuable reagent for researchers and industrial chemists seeking to create complex fluorinated molecules.
Organic Synthesis
Trifluoroacetyl chloride serves as a key reagent for trifluoroacetylation reactions. It is used to introduce the trifluoroacetyl group (CF3CO-) onto various nucleophiles, including alcohols, amines, and thiols. This is a crucial step in the synthesis of many fluorinated organic compounds.
Pharmaceutical Intermediates
The trifluoroacetyl moiety is present in numerous pharmacologically active molecules. Trifluoroacetyl chloride is therefore utilised in the multi-step synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs), contributing to the development of novel therapeutics.
Specialty Chemical Production
This compound finds application in the production of specialty chemicals where the incorporation of fluorine atoms imparts unique properties. It is valuable in the synthesis of agrochemicals, advanced materials, and specialised reagents.
| Molecular weight | 132.47 |
|---|---|
| Linear formula | CF3COCl |
| Assay | 98% |
| Boiling point | −27 °C(lit.) |
| Vapour density | 4.6 (vs air) |
| Melting point | −146 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) |
|---|---|
| Transport (UN / ADR) | UN 3057 8(2.3) |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-35-37 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trifluoroacetyl chloride used for?
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Trifluoroacetyl chloride is primarily used as a trifluoroacetylating agent in organic synthesis. It is employed in the introduction of the trifluoroacetyl group into alcohols, amines, and other nucleophiles, forming crucial intermediates for pharmaceuticals, agrochemicals, and specialty materials.
What is the CAS number and chemical formula for Trifluoroacetyl chloride?
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The CAS number for Trifluoroacetyl chloride is 354-32-5, and its linear chemical formula is CF3COCl.
What grade and purity does Tech Serve Solutions supply for Trifluoroacetyl chloride?
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Tech Serve Solutions supplies Trifluoroacetyl chloride with an assay of 98%. This is a technical/research grade, and TSS does not represent it as USP, BP, or EP grade.
How should Trifluoroacetyl chloride be handled safely?
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Trifluoroacetyl chloride is a highly corrosive substance that reacts violently with water, releasing hazardous fumes. Handle with extreme care in a well-ventilated area or fume hood, using appropriate personal protective equipment including faceshields, gloves, goggles, and a full-face or multi-purpose respirator. Avoid contact with skin, eyes, and inhalation of vapours.
Is Trifluoroacetyl chloride a controlled substance?
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The provided data does not indicate that Trifluoroacetyl chloride is a controlled substance.
How is Trifluoroacetyl chloride packed and exported by TSS?
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As a specialty gas, Trifluoroacetyl chloride is handled with stringent safety protocols. Specific packaging and export procedures adhere to international regulations for hazardous materials, ensuring safe transit. Please contact TSS for detailed shipping and export information.
How can I request a quote or sample for Trifluoroacetyl chloride?
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To request a quote or a sample of Trifluoroacetyl chloride, please contact the Tech Serve Solutions sales team via our website or by phone. Our experts will be pleased to assist you with your inquiry.
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