TIQ-A

CAS 420849-22-5C11H7NOSBiochemicals & Reagents

TIQ-A (CAS: 420849-22-5), with the molecular formula C11H7NOS and a molecular weight of 201.24 g/mol, is a thieno[2,3-c]isoquinolin-5-one derivative. This compound functions as a potent inhibitor, primarily studied for its role in biological pathways. Its applications include research into inflammatory responses and the regression of atherosclerotic plaques.

IUPAC: Thieno[2,3-c]isoquinolin-5-one

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TIQ-A (C11H7NOS) — chemical structure, CAS 420849-22-5; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesP to QT More...

01 /Applications

Inhibition of Poly(ADP-ribose) Polymerase (PARP)

TIQ-A serves as a Poly(ADP-ribose) Polymerase (PARP) inhibitor. It has been utilised in research to investigate the role of PARP in biological processes, including inflammatory responses and cellular signalling pathways.

Research in Inflammatory Conditions

This compound has been employed in studies examining eosinophilic infiltration into the airways of mice challenged with ovalbumin (OVA). Its inhibitory action helps elucidate the mechanisms behind allergic inflammation.

Studies on Atherosclerosis Regression

TIQ-A has been investigated for its potential role in the regression of atherosclerotic plaques. Research has utilised this inhibitor in high-fat diet-induced models in ApoE(-/-) mice to understand its therapeutic implications.

02 /Properties

Molecular weight	201.24
Empirical formula	C11H7NOS
Assay	≥98% (HPLC)
Form	solid
Solubility	DMSO: soluble16 mg/mL
Storage temperature	2-8°C
Application	TIQ-A has been used as a PAPR-1 inhibitor to study eosinophilic infiltration into the airways of OVA-challenged mice1. It has also been used to study its role in the regression of atherosclerotic plaques in high-fat diet-fed ApoE(-/-) mice2.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	20/21/22

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

420849-22-5

MDL number

MFCD06407947

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is TIQ-A used for?

TIQ-A is used as a Poly(ADP-ribose) Polymerase (PARP) inhibitor in research, particularly in studies concerning inflammatory conditions like eosinophilic airway infiltration and the regression of atherosclerotic plaques.

What is the CAS number and molecular formula for TIQ-A?

The CAS number for TIQ-A is 420849-22-5, and its molecular formula is C11H7NOS.

What grade and purity does Tech Serve Solutions supply for TIQ-A?

Tech Serve Solutions supplies TIQ-A with a purity of ≥98% (HPLC). This product is supplied for research purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.

How should TIQ-A be handled and stored?

TIQ-A is classified as harmful if swallowed, in contact with skin, or if inhaled (H302-H312-H332). It should be handled with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, in a well-ventilated area. Store at 2-8°C.

Is TIQ-A shipped internationally?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including TIQ-A, and can facilitate international shipments.

How can I request a sample or quote for TIQ-A?

To request a sample or a quotation for TIQ-A, please contact our sales department through the website or via direct email, providing your specific requirements.