TDZD-8

CAS 327036-89-5C10H10N2O2SBiochemicals & Reagents

TDZD-8 (CAS 327036-89-5), with the molecular formula C10H10N2O2S and a molecular weight of 222.26 g/mol, is supplied as white needles. This compound is recognised for its utility in biochemical research, particularly as an inhibitor of Glycogen Synthase Kinase 3 (GSK-3). Its applications extend to studying cellular processes, including its role in maintaining specific transcriptional programs in leukemia stem cells and its effects on neural functions within the mouse olfactory bulb.

IUPAC: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Synonyms: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

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TDZD-8 (C10H10N2O2S) — chemical structure, CAS 327036-89-5; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyD to KEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesGlycogen synthase kinase

01 /Applications

GSK-3 Inhibition Studies

TDZD-8 serves as a selective inhibitor for Glycogen Synthase Kinase 3 (GSK-3). It is employed in research to elucidate the signaling pathways regulated by GSK-3 in various biological contexts.

Leukemia Stem Cell Research

This compound has been utilised to investigate the function of GSK-3 in sustaining the transcriptional programs essential for MLL leukemia stem cell viability and proliferation.

Neuroscience and Neural Function Research

TDZD-8 has been applied to study its impact on the neural functions of the mouse olfactory bulb, contributing to the understanding of neurobiological processes.

02 /Properties

Molecular weight	222.26
Empirical formula	C10H10N2O2S
Assay	≥98% (HPLC)
Form	needles
Colour	white
Solubility	DMSO: >10 mg/mL
Storage temperature	2-8°C
Melting point	63-64.4 °C
Application	TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program1. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb2.

03 /Safety & handling

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H334May cause allergy or asthma symptoms if inhaled

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P342

Protective equipment	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	43
Safety statements (S)	36/37

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

327036-89-5

05 /Additional specifications

Storage Condition	protect from light

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is TDZD-8 used for?

TDZD-8 is used in biochemical research as a Glycogen Synthase Kinase 3 (GSK-3) inhibitor. It has been applied to study its role in maintaining MLL leukemia stem cell transcriptional programs and its effects on neural functions in the mouse olfactory bulb.

What are the CAS number and formula for TDZD-8?

The CAS number for TDZD-8 is 327036-89-5, and its empirical formula is C10H10N2O2S.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies TDZD-8 with an assay of ≥98% by HPLC. We do not represent this product as USP, BP, or EP grade.

How should TDZD-8 be handled safely?

Due to potential respiratory sensitisation (H334), handle TDZD-8 with appropriate personal protective equipment, including a dust mask (N95 or equivalent), eyeshields, faceshields, and gloves. Ensure adequate ventilation. Store in a cool, dry place away from light.

How is TDZD-8 packaged and shipped?

TDZD-8 is typically packaged as white needles and stored under refrigeration at 2-8°C, protected from light. It is exported globally by Tech Serve Solutions adhering to all necessary regulations.