Thiophosgene
Thiophosgene (CAS 463-71-8), with the linear formula CSCl₂, is a crucial reagent in organic synthesis. Possessing a molecular weight of 114.98 g/mol, it serves as a precursor for synthesizing various sulfur-containing organic compounds. Its primary application involves the preparation of thiourea ligands, which are vital in palladium-catalyzed reactions for the oxidation of alcohols to aldehydes and ketones, facilitating advanced chemical transformations.
- IUPAC
- Thiocarbonyl chloride
- Synonyms
- Thiocarbonyl chloride
Synthesis of Thiourea Ligands
Thiophosgene is used to prepare bulky thiourea ligands. These ligands are essential components in palladium-catalyzed aerobic oxidation reactions, enabling the efficient conversion of alcohols into aldehydes and ketones.
Organic Synthesis Reagent
As a versatile reagent in organic synthesis, thiophosgene is employed in the creation of diverse sulfur-containing heterocyclic compounds and functionalised molecules, contributing to complex molecular architecture.
Phosgene Derivative Chemistry
It functions as a key derivative of phosgene, offering a reactive thiocarbonyl group for various synthetic transformations and the introduction of sulfur into organic frameworks.
| Molecular weight | 114.98 |
|---|---|
| Linear formula | CSCl2 |
| Boiling point | 70-75 °C(lit.) |
| Density | 1.50 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.548(lit.) |
| Vapour density | 4 (vs air) |
| Storage temperature | 2-8°C |
| Application | Reagent used to prepare a bulky thiourea ligand for palladium-catalyzed aerobic oxidation of alcohols to aldehydes and ketones.1 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H331Toxic if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 2474 6.1 / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | T |
| Risk statements (R) | 22-23-36/37/38 |
| Safety statements (S) | 7-9-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Thiophosgene used for?
+
Thiophosgene (CAS 463-71-8) is primarily used as a reagent in organic synthesis, notably for preparing thiourea ligands used in palladium-catalyzed oxidation of alcohols to aldehydes and ketones.
What is the CAS number and formula for Thiophosgene?
+
The CAS number for Thiophosgene is 463-71-8, and its linear formula is CSCl₂.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Thiophosgene as a reagent grade chemical. We do not represent it as USP, BP, EP, or for any pharmacopoeia, food, or nutraceutical use. Please refer to the product specifications for detailed purity information.
How should Thiophosgene be handled safely?
+
Thiophosgene is a hazardous substance (GHS06, Danger). It is harmful if swallowed (H302), causes skin irritation (H315), serious eye irritation (H319), and is toxic if inhaled (H331), and may cause respiratory irritation (H335). Always use appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection like a full-face respirator or an appropriate cartridge (e.g., ABEK).
How is Thiophosgene packed and shipped?
+
Thiophosgene is carefully packed according to international regulations for hazardous materials. It is shipped under UN 2474, Class 6.1, Packing Group II. Contact TSS for detailed export and shipping information.
How can I request a sample or quote for Thiophosgene?
+
To request a sample or a quote for Thiophosgene, please contact the Tech Serve Solutions sales team through our website or by calling our direct line. Please specify the quantity and delivery location.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis