Thiourea
Thiourea (CAS: 62-56-6) is an organosulfur compound with the molecular formula NH 2CSNH 2 and a molecular weight of 76.12 g/mol. It functions as a chaotropic agent and a strong denaturant, recognised for its ability to increase protein solubility and recovery. Thiourea is widely employed in chemical synthesis and various life science research applications, particularly in molecular biology and proteomics.
- IUPAC
- Sulfourea,Thiocarbamide
- Synonyms
- SulfoureaThiocarbamide
Protein Denaturation and Solubility Enhancement
As a potent chaotropic agent, thiourea disrupts protein secondary and tertiary structures, facilitating denaturation. This property is crucial for increasing the solubility and recovery of proteins during purification processes.
Chemical Synthesis Intermediate
Thiourea serves as a versatile building block in organic synthesis. It is used in the preparation of various heterocyclic compounds and pharmaceuticals.
Research Reagent
In molecular biology and cell biology research, thiourea is utilized for its denaturing capabilities, aiding in studies involving protein structure and function, including techniques like SDS-PAGE.
| Molecular weight | 76.12 |
|---|---|
| Linear formula | NH2CSNH2 |
| Assay | ≥98.0% |
| Grade | ACS reagent |
| Solubility | H2O: passes test |
| Loss on drying | ≤0.5% loss on drying |
| Application | Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins |
| Melting point | 170-176 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H351Suspected of causing cancer
- H361D
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P281Use personal protective equipment as required
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 63-22-40-51/53 |
| Safety statements (S) | 36/37-61 |
| Ignition residue | ≤0.1% (as SO4) |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | mouse ... Ephx2(13850) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Thiourea used for?
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Thiourea is primarily used as a chaotropic agent and strong denaturant to increase protein solubility and recovery, and as a building block in chemical synthesis.
What is the CAS number and formula for Thiourea?
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The CAS number for Thiourea is 62-56-6, and its linear formula is NH 2CSNH 2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Thiourea in ACS reagent grade with an assay of ≥98.0%.
How should Thiourea be handled safely?
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Thiourea is harmful if swallowed, suspected of causing cancer, suspected of damaging fertility or the unborn child, and toxic to aquatic life with long lasting effects. Always consult the Safety Data Sheet and use appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection.
How is Thiourea packed and shipped?
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Thiourea is packed and shipped according to international regulations for hazardous materials, including UN 3077 9 / PGIII classification.
How can I request a sample or quote for Thiourea?
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Please contact our sales team via the website or direct email to request a sample or a quotation for Thiourea.
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