Thiophosphoryl chloride
Thiophosphoryl chloride (CAS: 3982-91-0) is a chemical compound with the linear formula PSCl3 and a molecular weight of 169.40 g/mol. This compound serves as a valuable reagent in chemical synthesis, particularly in the preparation of organophosphorus compounds. Its reactivity makes it useful in the development of various materials and complex molecules.
- IUPAC
- Phosphorus sulfochloride,Phosphorus thiochloride
- Synonyms
- Phosphorus sulfochloridePhosphorus thiochloride

Synthesis of Organophosphorus Compounds
Thiophosphoryl chloride is employed as a building block in the synthesis of specialized organophosphorus compounds. It facilitates the introduction of the thiophosphoryl group, which is crucial in creating diverse molecular structures.
Material Science Research
This chemical is utilized in materials science, contributing to the development of novel materials such as dendrimers and nanomaterials. Its specific reactivity allows for controlled incorporation into polymer backbones or nanostructures.
Preparation of Intermediates
Thiophosphoryl chloride is used in the synthesis of intermediate compounds, for example, in the preparation of O-ethyl dichlorothiophosphate. These intermediates are vital for further chemical transformations in various research and industrial processes.
| Molecular weight | 169.40 |
|---|---|
| Linear formula | PSCl3 |
| Assay | 98% |
| Boiling point | 125 °C(lit.) |
| Density | 1.668 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.555(lit.) |
| Solubility | benzene: soluble(lit.)carbon disulfide: soluble(lit.)carbon tetrachloride: soluble(lit.)chloroform: soluble(lit.) |
| Melting point | −35 °C(lit.) |
| Application | Thiophosphoryl chloride was used in the synthesis of O-ethyl dichlorothiophosphate1. |


Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 1837 8 / PGII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 22-26-34-52/53 |
| Safety statements (S) | 26-28-36/37/39-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Thiophosphoryl chloride primarily used for?
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Thiophosphoryl chloride is used as a building block in chemical synthesis, particularly for creating organophosphorus compounds, dendrimers, and nanomaterials. It was also used in the synthesis of O-ethyl dichlorothiophosphate.
What is the CAS number and chemical formula for Thiophosphoryl chloride?
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The CAS number for Thiophosphoryl chloride is 3982-91-0, and its linear formula is PSCl3.
What grade and purity does Tech Serve Solutions supply for Thiophosphoryl chloride?
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Tech Serve Solutions supplies Thiophosphoryl chloride with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
What are the main safety hazards associated with Thiophosphoryl chloride?
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Thiophosphoryl chloride is classified as Danger. It is harmful if swallowed (H302), causes severe skin burns and eye damage (H314), and is fatal if inhaled (H330). Appropriate personal protective equipment, including respirators, gloves, and eye protection, is essential for safe handling.
How is Thiophosphoryl chloride typically packed and exported?
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Thiophosphoryl chloride is packed according to relevant safety regulations for hazardous materials, including UN 1837 classification, and is exported globally by TSS.
How can I request a quote or sample for Thiophosphoryl chloride?
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To request a quote or sample of Thiophosphoryl chloride, please contact our sales team through the website or direct inquiry.
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