Thiophene
Thiophene (CAS: 110-02-1, Formula: C4H4S, MW: 84.14) is a volatile, flammable heterocyclic organic compound. As a fundamental building block in organic synthesis, it is crucial for constructing more complex molecules. Thiophene and its derivatives find significant utility in the development of pharmaceuticals, agrochemicals, and advanced materials, particularly in organic electronics.
- IUPAC
- Thiofuran,Thiole
- Synonyms
- ThiofuranThiole

Pharmaceutical Synthesis
Thiophene serves as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Its structure can be incorporated into drug molecules to modulate pharmacological properties.
Agrochemical Development
Derivatives of thiophene are utilized in the creation of pesticides, herbicides, and fungicides. The thiophene ring can impart specific biological activities relevant to crop protection.
Materials Science
Thiophene is a foundational component for conducting polymers and organic semiconductors. These materials are essential for applications in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
Research and Development
As a versatile building block, thiophene is widely employed in academic and industrial research laboratories for exploring new chemical reactions and synthesizing novel compounds.
| Molecular weight | 84.14 |
|---|---|
| Empirical formula | C4H4S |
| Assay | ≥99% |
| Boiling point | 84 °C(lit.) |
| Density | 1.051 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.529(lit.) |
| Vapour pressure | 40 mmHg (12.5 °C) |
| Melting point | −38 °C(lit.) |
| Vapour density | 2.9 (vs air) |
| Autoignition temp | 743 °F |



Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H331Toxic if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -1 °C / 30.2 °F |
| Transport (UN / ADR) | UN 2414 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-20/22-37/38-41 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Thiophene primarily used for?
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Thiophene is primarily used as a building block in organic synthesis, crucial for developing pharmaceuticals, agrochemicals, and materials for organic electronics.
What is the CAS number and chemical formula for Thiophene?
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The CAS number for Thiophene is 110-02-1, and its chemical formula is C4H4S.
What grade and purity does Tech Serve Solutions supply for Thiophene?
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Tech Serve Solutions supplies Thiophene with an assay of ≥99%. We do not represent this product as USP, BP, or EP grade.
How should Thiophene be handled safely?
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Thiophene is highly flammable (Flash Point: -1 °C) and harmful if swallowed, causes skin irritation, serious eye damage, and is toxic if inhaled. Handle with appropriate personal protective equipment, including safety eyeshields, gloves, and a suitable respirator, in a well-ventilated area away from ignition sources.
Can Tech Serve Solutions export Thiophene globally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Thiophene.
How can I request a quote or sample for Thiophene?
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To request a quote or sample for Thiophene, please contact our sales team through the website or by phone.
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