Thiomorpholine

CAS 123-90-0C4H9NSChemical Synthesis

Thiomorpholine (CAS: 123-90-0), with the empirical formula C4H9NS and a molecular weight of 103.19 g/mol, is a heterocyclic organic compound. It serves as a valuable building block in chemical synthesis, particularly in the creation of specialised organic molecules. Its applications are found in research and development settings for the preparation of complex compounds. Tech Serve Solutions supplies this chemical with a minimum assay of 97.0%.

IUPAC: Tetrahydro-2H-1,4-thiazine,Thiamorpholine

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Thiomorpholine (C4H9NS) — chemical structure, CAS 123-90-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksC4 to C10Chemical SynthesisHeterocyclic Building BlocksMorpholines/Thiomorpholines

01 /Applications

Synthesis of Amino Acid Derivatives

Thiomorpholine is employed in the preparation of modified amino acids, such as N-Boc-α-alkyl-β-(sec-amino)alanines, which are useful intermediates in peptide chemistry and drug discovery.

Preparation of Borane Complexes

It is utilised in the synthesis of thiomorpholine-N-borane, a reagent with applications in organic synthesis, particularly in hydroboration reactions and as a reducing agent.

Heterocyclic Chemistry

As a morpholine analogue containing sulfur, thiomorpholine is a key heterocycle in medicinal chemistry and materials science research for developing novel molecular scaffolds.

02 /Properties

Molecular weight	103.19
Empirical formula	C4H9NS
Assay	≥97.0% (GC)
Boiling point	169 °C(lit.)
Density	1.026 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.538(lit.)n20/D 1.540
Application	Thiomorpholine has been used in the preparation of:• N-Boc-α-alkyl-β-(sec-amino)alanines1• thiomorpholine-N-borane2

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	63 °C / 145.4 °F
Transport (UN / ADR)	UN 3267 8 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	C
Risk statements (R)	34-37
Safety statements (S)	26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

123-90-0

MDL number

MFCD00005974

PubChem substance

24851748

Beilstein registry

102550

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Thiomorpholine used for?

Thiomorpholine (CAS: 123-90-0) is primarily used as a building block in chemical synthesis, notably for preparing N-Boc-α-alkyl-β-(sec-amino)alanines and thiomorpholine-N-borane.

What is the CAS number and chemical formula for Thiomorpholine?

The CAS number for Thiomorpholine is 123-90-0, and its chemical formula is C4H9NS.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Thiomorpholine with a minimum assay of ≥97.0% (GC). This is a technical grade suitable for research and chemical synthesis; TSS does not represent it as USP, BP, or EP grade.

How should Thiomorpholine be handled safely?

Thiomorpholine is corrosive and can cause severe skin burns and eye damage (H314). Appropriate personal protective equipment, including face shields, gloves, goggles, and suitable respirator filters (type ABEK), must be worn. Handle in a well-ventilated area, and seek immediate medical attention in case of contact or ingestion.

Is Thiomorpholine a controlled substance?

The provided data does not indicate that Thiomorpholine (CAS: 123-90-0) is a controlled substance.

How is Thiomorpholine shipped and exported?

Thiomorpholine is classified under UN 3267, Class 8, Packing Group III (corrosive liquid, acidic, organic, n.o.s.). Shipments are handled in accordance with international dangerous goods regulations.

How can I request a quote or sample of Thiomorpholine?

To request a quote or sample of Thiomorpholine, please contact Tech Serve Solutions directly through our website or sales department, providing your required quantity and shipping details.