tert-Butyldimethylsilyl bromoacetate
Tert-Butyldimethylsilyl bromoacetate (CAS 480439-46-1) is an organic ester with the linear formula BrCH2CO2Si(CH3)2C(CH3)3 and a molecular weight of 253.21 g/mol. This compound serves as a valuable building block in organic synthesis, particularly in reactions involving ester and silyl ether functionalities. Its utility extends to the preparation of more complex molecules within pharmaceutical and chemical research settings.
Organic Synthesis Intermediate
Tert-Butyldimethylsilyl bromoacetate is employed as a key intermediate in multi-step organic synthesis. It facilitates the introduction of protected acetate groups or can be involved in alkylation reactions.
Protecting Group Chemistry
The tert-butyldimethylsilyl (TBDMS) moiety provides a robust yet cleavable protecting group for carboxylic acids. This compound can be used to install the TBDMS-protected acetate functionality onto various substrates.
Pharmaceutical Research
This compound finds application in the synthesis of novel pharmaceutical candidates and complex organic molecules investigated for biological activity.
Material Science Precursor
It may be utilised in the development of novel materials where specific organic functionalities are required for polymerisation or surface modification.
| Molecular weight | 253.21 |
|---|---|
| Linear formula | BrCH2CO2Si(CH3)2C(CH3)3 |
| Assay | 97% |
| Boiling point | 60-62 °C/0.1 mmHg(lit.) |
| Density | 1.186 g/mL at 25 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 95 °C / 203 °F |
| Transport (UN / ADR) | UN 3267 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tert-Butyldimethylsilyl bromoacetate used for?
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Tert-Butyldimethylsilyl bromoacetate is primarily used as a building block in organic synthesis, for introducing protected acetate groups, and in pharmaceutical research.
What is the CAS number and formula for tert-Butyldimethylsilyl bromoacetate?
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The CAS number is 480439-46-1 and the linear formula is BrCH2CO2Si(CH3)2C(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies tert-Butyldimethylsilyl bromoacetate with a minimum assay of 97%. This product is suitable for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should tert-Butyldimethylsilyl bromoacetate be handled safely?
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Tert-Butyldimethylsilyl bromoacetate is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including faces, gloves, and respiratory protection, must be used. Handle only in well-ventilated areas and follow all safety precautions.
Is tert-Butyldimethylsilyl bromoacetate a controlled substance?
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The provided data does not indicate that tert-Butyldimethylsilyl bromoacetate is a controlled substance.
How is tert-Butyldimethylsilyl bromoacetate packed and exported?
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This compound is packed and shipped according to international regulations for hazardous materials, identified under UN 3267, Class 8, Packing Group II. TSS exports globally, adhering to all shipping and customs requirements.
How can I request a quote or sample of tert-Butyldimethylsilyl bromoacetate?
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To request a quote or a sample, please visit the Tech Serve Solutions website and use the contact form or product inquiry option, providing the CAS number 480439-46-1.
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