tert-Butyldimethylsilyl chloroacetate
Tert-Butyldimethylsilyl chloroacetate (CAS 480439-47-2) is an organosilicon compound with the linear formula ClCH₂CO₂Si(CH₃)₂C(CH₃)₃ and a molecular weight of 208.76 g/mol. This ester serves as a valuable building block in organic synthesis, particularly for introducing protected acetate functionalities. Its physical properties include a refractive index of 1.437(lit.), a boiling point of 48-49 °C/0.2 mmHg, and a density of 1.001 g/mL at 25 °C.
Organic Synthesis Reagent
Used as a versatile building block in complex organic molecule construction. It enables the introduction of protected acetoxy groups, facilitating multistep synthetic pathways.
Protecting Group Chemistry
The tert-butyldimethylsilyl moiety provides a robust protecting group for carboxylic acids or hydroxyl groups during chemical transformations. It can be selectively removed under specific conditions.
Pharmaceutical Intermediate
Employed in the synthesis of active pharmaceutical ingredients (APIs) and their precursors. Its utility lies in enabling precise chemical modifications necessary for drug development.
Research and Development
A key reagent in academic and industrial research laboratories for exploring new synthetic methodologies and developing novel compounds with potential applications.
| Molecular weight | 208.76 |
|---|---|
| Linear formula | ClCH2CO2Si(CH3)2C(CH3)3 |
| Assay | 97% |
| Boiling point | 48-49 °C/0.2 mmHg(lit.) |
| Density | 1.001 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.437(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 67 °C / 152.6 °F |
| Transport (UN / ADR) | UN 3267 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tert-Butyldimethylsilyl chloroacetate used for?
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Tert-Butyldimethylsilyl chloroacetate is primarily used as a building block in organic synthesis for introducing protected acetate functionalities and in the development of pharmaceutical intermediates.
What are the CAS number and formula for tert-Butyldimethylsilyl chloroacetate?
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The CAS number is 480439-47-2 and the linear formula is ClCH₂CO₂Si(CH₃)₂C(CH₃)₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies tert-Butyldimethylsilyl chloroacetate with an assay of 97%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the primary safety hazards associated with tert-Butyldimethylsilyl chloroacetate?
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This compound is classified as Danger, with hazard statement H314, indicating it causes severe skin burns and eye damage. Appropriate personal protective equipment, including full-face respirators, gloves, and eye protection, must be used.
How is tert-Butyldimethylsilyl chloroacetate packed and shipped?
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Tert-Butyldimethylsilyl chloroacetate is packed and shipped according to international regulations for hazardous materials, designated as UN 3267, Class 8, Packing Group II.
How can I request a sample or quote for tert-Butyldimethylsilyl chloroacetate?
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Please contact our sales team directly through our website or by phone to request a sample or a quotation for tert-Butyldimethylsilyl chloroacetate.
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