tert-Butyldimethylsilyl cyanide
Tert-Butyldimethylsilyl cyanide (CAS 56522-24-8) is a specialised organosilicon compound with the linear formula (CH3)3CSi(CH3)2CN and a molecular weight of 141.29 g/mol. It serves as a valuable building block in organic synthesis, particularly for introducing the cyano group in the synthesis of complex molecules. Its utility is primarily found in chemical research and development settings for creating new carbon-carbon bonds.
- IUPAC
- tert-Butyl-cyano-dimethylsilane
- Synonyms
- tert-Butyl-cyano-dimethylsilane

Cyanation Reagent
This compound is employed as a reagent for the introduction of cyanide groups into organic molecules. It facilitates cyanation reactions, which are fundamental in the construction of carbon skeletons for pharmaceuticals and agrochemicals.
Organic Synthesis Intermediate
Tert-Butyldimethylsilyl cyanide functions as a versatile intermediate in multi-step organic syntheses. It enables chemists to build complex molecular architectures and introduce nitrogen-containing functionalities.
Research and Development
Utilised in academic and industrial research laboratories, this chemical aids in exploring novel synthetic routes and developing new chemical entities. Its specific reactivity profile is valuable for targeted transformations.
| Molecular weight | 141.29 |
|---|---|
| Linear formula | (CH3)3CSi(CH3)2CN |
| Assay | 97% |
| Melting point | 76-79 °C(lit.) |

Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25 |
| Safety statements (S) | 36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tert-Butyldimethylsilyl cyanide used for?
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Tert-Butyldimethylsilyl cyanide is used as a reagent for cyanation reactions and as an intermediate in organic synthesis, particularly in research and development for creating complex molecules.
What is the CAS number and formula for Tert-Butyldimethylsilyl cyanide?
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The CAS number is 56522-24-8 and the linear formula is (CH3)3CSi(CH3)2CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tert-Butyldimethylsilyl cyanide with a purity of 97%. This is a technical grade and is not represented as USP, BP, EP, or any other pharmacopoeia standard.
How should Tert-Butyldimethylsilyl cyanide be handled safely?
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Due to its toxicity (H301-H311-H331), handle with extreme caution using appropriate personal protective equipment including eyeshields, faceshields, gloves, and a P2 respirator. Ensure adequate ventilation and follow emergency procedures (P301 + P310-P311).
Is Tert-Butyldimethylsilyl cyanide a controlled substance?
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The provided data indicates hazard codes 'T' (Toxic) and RIDADR UN 2811 6.1, classifying it as toxic. It is not explicitly listed as a scheduled or controlled substance in the provided safety information.
How is Tert-Butyldimethylsilyl cyanide packed, shipped, and exported?
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As a global supplier, Tech Serve Solutions expertly packs, ships, and exports chemicals like Tert-Butyldimethylsilyl cyanide in compliance with international regulations for hazardous materials.
How can I request a sample or quote for Tert-Butyldimethylsilyl cyanide?
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To request a sample or a quote, please contact our sales team via the website or direct contact details provided.
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