tert-Butyldimethylsilane
Tert-Butyldimethylsilane (CAS 29681-57-0), with the molecular formula (CH3)3CSiH(CH3)2 and a molecular weight of 116.28 g/mol, is an organosilicon compound. This flammable liquid is primarily utilised as a reagent in organic synthesis, particularly in the formation and protection of silyl ethers and as a precursor in various chemical transformations. Its chemical properties make it a valuable tool in complex molecular construction.

Reagent in Organic Synthesis
Tert-Butyldimethylsilane serves as a key reagent in organic synthesis, participating in reactions such as the formation of silyl ethers, which are crucial protecting groups for alcohols.
Organosilicon Chemistry
As an organosilicon compound, it is employed in research and development within organosilicon chemistry, contributing to the synthesis of novel silicon-containing materials and molecules.
Protecting Group Chemistry
Its structure allows for the selective protection of functional groups, particularly hydroxyl groups, enabling chemists to carry out multi-step syntheses with greater control and efficiency.
| Molecular weight | 116.28 |
|---|---|
| Linear formula | (CH3)3CSiH(CH3)2 |
| Assay | 95% |
| Boiling point | 81-83 °C(lit.) |
| Density | 0.701 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4(lit.) |


Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -11 °C / 12.2 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tert-Butyldimethylsilane used for?
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Tert-Butyldimethylsilane (CAS 29681-57-0) is primarily used as a reagent in organic synthesis, particularly for the formation of silyl ethers and as a protective group in complex chemical transformations.
What are the CAS number and molecular formula for tert-Butyldimethylsilane?
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The CAS number for tert-Butyldimethylsilane is 29681-57-0. Its molecular formula is (CH3)3CSiH(CH3)2.
What grade and purity does Tech Serve Solutions supply for tert-Butyldimethylsilane?
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Tech Serve Solutions supplies tert-Butyldimethylsilane with an assay of 95%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should tert-Butyldimethylsilane be handled safely?
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Tert-Butyldimethylsilane is a highly flammable liquid and vapour (H225) that causes skin (H315), serious eye (H319), and respiratory irritation (H335). Always handle in a well-ventilated area, away from ignition sources, and wear appropriate personal protective equipment including gloves and eye protection.
Is tert-Butyldimethylsilane suitable for export and international shipping?
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Yes, tert-Butyldimethylsilane is supplied and exported by Tech Serve Solutions. It is classified under UN 1993, BF 3 / PG II for transport.
How can I request a quote or sample of tert-Butyldimethylsilane?
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To request a quote or sample of tert-Butyldimethylsilane, please contact our sales team through the website or by phone, providing your specific requirements and shipping details.
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