(tert-Butyldimethylsilyl)acetylene
(tert-Butyldimethylsilyl)acetylene, CAS 86318-61-8, is an organosilicon compound with the linear formula (CH3)3CSi(CH3)2C≡CH and a molecular weight of 140.30. This terminal alkyne serves as a versatile building block in organic synthesis. Its unique structure, featuring a bulky tert-butyldimethylsilyl group protecting a terminal acetylene, makes it valuable for introducing ethynyl functionalities in complex molecule construction and for use in cross-coupling reactions.
- IUPAC
- Ethynyl-tert-butyldimethylsilane
- Synonyms
- Ethynyl-tert-butyldimethylsilane
Organic Synthesis Building Block
Utilised as a key intermediate in the synthesis of complex organic molecules, particularly in the construction of carbon-carbon bonds via cross-coupling reactions like Sonogashira coupling. The silyl group offers protection and can be readily removed under specific conditions.
Introduction of Terminal Alkyne
Enables the controlled introduction of a terminal alkyne moiety into target molecules. This functionality is crucial for subsequent derivatisation, such as click chemistry or further functional group transformations.
Research and Development
Employed in academic and industrial research laboratories for exploring novel synthetic pathways and developing new chemical entities within pharmaceutical and materials science sectors.
| Molecular weight | 140.30 |
|---|---|
| Linear formula | (CH3)3CSi(CH3)2C≡CH |
| Assay | ≥98.0% (GC) |
| Boiling point | 116-117 °C(lit.) |
| Density | 0.751 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.451(lit.) |
Hazard statements
- H225Highly flammable liquid and vapour
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 6 °C / 42.8 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
| Safety statements (S) | 9-16-23-24/25-29-33 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (tert-Butyldimethylsilyl)acetylene used for?
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(tert-Butyldimethylsilyl)acetylene is primarily used as a building block in organic synthesis to introduce terminal alkyne functionalities and in various cross-coupling reactions.
What is the CAS number and chemical formula for (tert-Butyldimethylsilyl)acetylene?
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The CAS number is 86318-61-8, and the linear chemical formula is (CH3)3CSi(CH3)2C≡CH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (tert-Butyldimethylsilyl)acetylene with a purity of ≥98.0% as determined by GC. This is a technical/research grade material, and TSS does not represent it as USP, BP, or EP grade.
How should (tert-Butyldimethylsilyl)acetylene be handled safely?
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This compound is highly flammable (H225) and requires careful handling. Use in a well-ventilated area, away from ignition sources. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (type ABEK respirator filter recommended), is essential. Always refer to the Safety Data Sheet for detailed guidance.
Is (tert-Butyldimethylsilyl)acetylene a controlled substance?
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Based on the provided data, there is no indication that (tert-Butyldimethylsilyl)acetylene is a controlled substance.
How is (tert-Butyldimethylsilyl)acetylene packed and exported?
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(tert-Butyldimethylsilyl)acetylene is classified under UN 1993 BF 3 / PG II and is shipped according to regulations for flammable liquids. TSS exports globally, adhering to all relevant international shipping and handling standards.
How can I request a sample or quote for (tert-Butyldimethylsilyl)acetylene?
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To request a sample or obtain a quote, please contact our sales department through the website or by phone, providing your specific requirements and shipping details.
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