Spironolactone
Spironolactone (CAS: 52-01-7, C24H32O4S) is a steroid derivative with a molecular weight of 416.57. It functions as an antagonist of aldosterone, primarily utilised in research settings to study renal function and its effects. Spironolactone serves as a valuable tool in biological and pharmacological investigations, particularly in endocrinology and cardiovascular research. Its specific chemical structure and properties make it a subject of interest for scientists exploring hormonal pathways and their physiological impacts.
- IUPAC
- 4-Pregnen-21-oic acid-17α-ol-3-one-7α-thiol γ-lactone 7-acetate,7α-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
- Synonyms
- 4-Pregnen-21-oic acid-17α-ol-3-one-7α-thiol γ-lactone 7-acetate7α-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
Research into Renal Function
Spironolactone is used in laboratory settings to investigate the long-term effects of aldosterone antagonism on kidney function in animal models, such as rats.
Pharmacological Studies
As a bioactive small molecule, Spironolactone is employed in studies examining hormonal mechanisms, cell signaling pathways, and the broader physiological impacts of steroid hormones.
Endocrinology Research
This compound is utilized in research focused on understanding the complex roles of hormones like androgens and corticosteroids in biological systems.
| Molecular weight | 416.57 |
|---|---|
| Empirical formula | C24H32O4S |
| Assay | 97.0-103.0% |
| Solubility | chloroform: complete50 mg/ml, clear, faintly yellow |
| Application | Spironolactone was added to rat diet to study the effect of long-term spironolactone use on renal function.1,2 |
| Melting point | 207-208 °C(lit.) |
Hazard statements
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 60 |
| Safety statements (S) | 53-22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... HSD17B1(3292), NR3C2(4306)rat ... Ar(24208) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Spironolactone used for?
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Spironolactone is primarily used in research settings to study the effects of aldosterone antagonism on renal function and hormonal pathways. It is a valuable tool for investigations in endocrinology, cell biology, and pharmacology.
What is the CAS number and formula for Spironolactone?
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The CAS number for Spironolactone is 52-01-7, and its empirical formula is C24H32O4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Spironolactone with an assay of 97.0-103.0%. We do not represent this product as USP, BP, or EP grade.
What are the primary safety concerns when handling Spironolactone?
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Spironolactone is classified as dangerous (GHS08, Signal Word: Danger) due to potential reproductive toxicity (H360). Handle with appropriate personal protective equipment, including eyeshields, gloves, and P2 respirator cartridges, in a well-ventilated area.
How is Spironolactone typically packed and shipped by TSS?
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Spironolactone is packaged according to industry standards to ensure safe transport and is exported globally by Tech Serve Solutions.
How can I request a quote or sample for Spironolactone?
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To request a quote or sample for Spironolactone, please contact our sales team through the website or by phone.
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