Sp-Guanosine 3′,5′-cyclic monophosphorothioate triethylammonium salt
Sp-Guanosine 3′,5′-cyclic monophosphorothioate triethylammonium salt (CAS: 86562-10-9) is a thio-modified analog of cyclic guanosine monophosphate (cGMP). This white, solid compound is primarily utilised in biochemical research to investigate cGMP-dependent pathways and enzyme activity. Its structure allows for stability and specific interactions within cellular signaling cascades, making it a valuable tool for researchers studying cyclic nucleotide metabolism and protein kinase G (PKG) activation.
- IUPAC
- Sp-Cyclic 3′5′-hydrogen phosphorothioate guanosine triethylammonium salt,Sp-cGMPS triethylammonium salt
- Synonyms
- Sp-Cyclic 3′5′-hydrogen phosphorothioate guanosine triethylammonium saltSp-cGMPS triethylammonium salt
Cell Signaling Research
Investigates the role of cyclic nucleotides and their analogs in cellular communication pathways. Sp-Guanosine 3′,5′-cyclic monophosphorothioate triethylammonium salt serves as a tool to probe cGMP-dependent signalling cascades.
Enzyme Activity Studies
Used to study the activity and regulation of enzymes involved in cyclic nucleotide metabolism, such as phosphodiesterases. Its thio-modified structure can offer different kinetic properties compared to native cGMP.
Protein Kinase G (PKG) Modulation
Acts as a substrate or activator in studies of Protein Kinase G (PKG) and its downstream effects. Researchers utilise this compound to understand PKG-mediated cellular responses in neuroscience and other fields.
Neuroscience Research
Employed in studies related to cell signaling in the nervous system, where cyclic nucleotides play crucial roles in neuronal function and plasticity. It aids in understanding pathways involving G proteins and cyclic nucleotides.
| Molecular weight | 462.46 |
|---|---|
| Empirical formula | C10H12N5O6PS · C6H15N |
| Form | solid |
| Colour | white |
| Solubility | H2O: soluble5 mg/mL |
| Storage temperature | −20°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | dry ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sp-Guanosine 3′,5′-cyclic monophosphorothioate triethylammonium salt used for?
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This compound is primarily used in biochemical research to investigate cyclic nucleotide metabolism, cell signaling pathways, and the activity of enzymes like protein kinase G (PKG).
What is the CAS number and formula for Sp-Guanosine 3′,5′-cyclic monophosphorothioate triethylammonium salt?
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The CAS number is 86562-10-9. The empirical formula (Hill notation) is C10H12N5O6PS · C6H15N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a research-grade chemical. We do not represent it as USP, BP, EP, or pharmacopoeia grade.
How should Sp-Guanosine 3′,5′-cyclic monophosphorothioate triethylammonium salt be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 or P1 respirator filter. It is classified under WGK Germany 3, indicating a hazard to water.
How is this product shipped and stored?
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This product is shipped in dry ice and should be stored at -20°C to maintain its stability and integrity.
How can I request a quote or sample?
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Please contact our sales team directly through our website or by phone to request a quote or a sample for Sp-Guanosine 3′,5′-cyclic monophosphorothioate triethylammonium salt.
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