Sp-8-pCPT-cAMPS

CAS 129693-13-6 (free acid)C16H14ClN5O5PS2NaCell Biology

Sp-8-pCPT-cAMPS, a sodium salt with CAS number 129693-13-6 and molecular formula C16H14ClN5O5PS2Na, is a potent and selective activator of Protein Kinase A (PKA). This bioactive small molecule is supplied as a solid, typically in a vial of 5 μmol, and shipped on dry ice. Its primary applications lie in cell biology research, particularly in studies of cell signaling, neuroscience, and kinase/phosphatase biology, aiding investigations into cyclic nucleotide pathways and their physiological effects.

IUPAC: 8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic monophosphorothioate, Sp-isomer sodium salt

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Sp-8-pCPT-cAMPS (C16H14ClN5O5PS2Na) — chemical structure, CAS 129693-13-6 (free acid); Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyKinase/Phosphatase BiologyProtein Kinase A (PKA)

01 /Applications

Protein Kinase A (PKA) Activation

Sp-8-pCPT-cAMPS is a well-established chemical tool for the direct activation of Protein Kinase A (PKA). It is used in biochemical and cell-based assays to study PKA-dependent signaling pathways and cellular responses.

Cell Signaling Research

This compound serves as a valuable reagent in cell signaling research, enabling scientists to investigate the role of cAMP-dependent pathways in various biological processes. Its selectivity helps in dissecting complex signaling cascades.

Neuroscience Investigations

In neuroscience, Sp-8-pCPT-cAMPS is employed to explore the involvement of PKA in neuronal function, synaptic plasticity, and other neurological processes. It facilitates the study of cyclic nucleotide roles in the central nervous system.

Kinase/Phosphatase Biology Studies

Researchers utilise this PKA activator to understand the intricate balance and cross-talk between kinase and phosphatase activities within cellular systems. It aids in characterising the substrates and functions regulated by PKA.

02 /Properties

Molecular weight	509.86
Empirical formula	C16H14ClN5O5PS2Na
Assay	≥98% (HPLC)
Form	solid
Solubility	H2O: >1 mg/mL
Storage temperature	−70°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

129693-13-6 (free acid)

MDL number

MFCD04113743

PubChem substance

24724452

05 /Additional specifications

Packaging	vial of 5 μmol
Shipped In	dry ice

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Sp-8-pCPT-cAMPS used for?

Sp-8-pCPT-cAMPS is primarily used as a selective activator of Protein Kinase A (PKA) in biochemical and cell-based research, aiding studies in cell signaling, neuroscience, and kinase/phosphatase biology.

What are the CAS number and formula for Sp-8-pCPT-cAMPS?

The CAS number for the free acid is 129693-13-6, and the sodium salt has the empirical formula C16H14ClN5O5PS2Na.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Sp-8-pCPT-cAMPS with an assay of ≥98% (HPLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated.

How should Sp-8-pCPT-cAMPS be handled?

When handling Sp-8-pCPT-cAMPS, it is recommended to use safety equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is a risk. The substance is classified with WGK 3 in Germany, indicating a high hazard to water.

How is Sp-8-pCPT-cAMPS packaged and shipped?

Sp-8-pCPT-cAMPS is supplied as a solid, typically in a vial containing 5 μmol. It is shipped on dry ice to maintain appropriate storage conditions during transit.

How can I request a quote or sample for Sp-8-pCPT-cAMPS?

To request a quote or sample of Sp-8-pCPT-cAMPS, please contact our sales team through the website or by phone, providing the product name and CAS number.