Splitomicin

CAS 5690-03-9C13H10O2Cell Biology

Splitomicin (CAS: 5690-03-9), a bioactive small molecule with the empirical formula C13H10O2 and a molecular weight of 198.22 g/mol, serves as a valuable tool in epigenetic research. This compound is primarily recognised for its role in inhibiting sirtuin activity, particularly SIRT1, making it useful for studies in cell biology, cell signalling, and neuroscience. Its applications extend to investigating gene regulation and transcription processes within various cellular models.

IUPAC: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Synonyms: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

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Splitomicin (C13H10O2) — chemical structure, CAS 5690-03-9; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyEpigeneticsMolecular BiologyOther HDAC InhibitorsS More...

01 /Applications

SIRT1 Inhibition Studies

Splitomicin has been employed to inhibit SIRT1 activity in human aortic endothelial cells, facilitating research into the role of this enzyme in cellular processes and disease mechanisms. It is also used to investigate sirtuin function in human breast cancer cells.

Cholesterol Efflux Research

In studies involving cholesterol metabolism, Splitomicin has been used to treat mouse leukaemic monocyte macrophage cell lines prior to cholesterol efflux assays, aiding in the understanding of cellular lipid transport mechanisms.

Epigenetic and Gene Regulation Research

As a DNA-RNA transcription regulator, Splitomicin is utilised in broader epigenetic research to explore mechanisms of gene regulation and expression, impacting fields such as molecular biology and cell signalling.

02 /Properties

Molecular weight	198.22
Empirical formula	C13H10O2
Assay	≥98% (HPLC)
Form	powder
Storage temperature	2-8°C
Application	Splitomicin was used to inhibit SIRT1 in human aortic endothelial cells1,2 and sirtuins in human breast cancer cells.3 Mouse leukaemic monocyte macrophage cell line was treated with Splitomicin prior to cholesterol efflux studies.4

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

5690-03-9

MDL number

MFCD08705254

PubChem substance

24724608

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Splitomicin used for?

Splitomicin is primarily used as a tool in epigenetic research for inhibiting sirtuin activity, particularly SIRT1, and for studies in cell biology, cell signalling, neuroscience, and gene regulation.

What are the CAS number and formula for Splitomicin?

The CAS number for Splitomicin is 5690-03-9, and its empirical formula is C13H10O2.

What grade and purity does Tech Serve Solutions supply for Splitomicin?

Tech Serve Solutions supplies Splitomicin with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.

How should Splitomicin be handled and stored?

For safe handling, use eyeshields and gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Splitomicin should be stored at 2-8°C. The WGK Germany is 3.

Is Splitomicin a controlled substance?

The provided data does not indicate that Splitomicin is a controlled substance.

How is Splitomicin packed and shipped?

Splitomicin is supplied as a powder and is available for export globally by Tech Serve Solutions, adhering to all necessary regulations for chemical shipments.