Spermine tetrahydrochloride
Spermine tetrahydrochloride (CAS: 306-67-2), with the molecular formula C10H26N4 · 4HCl and a molecular weight of 348.18 g/mol, is a salt form of spermine. This white to off-white powder is highly soluble in water. It is primarily recognised for its utility in precipitating DNA from low-salt aqueous solutions. Spermine tetrahydrochloride finds applications in biochemical research, particularly in studies involving nucleic acids and cell biology.
- IUPAC
- N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
- Synonyms
- N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
DNA Precipitation
Spermine tetrahydrochloride is employed to facilitate the precipitation of DNA from aqueous buffers with low salt concentrations. This property is valuable in molecular biology workflows for DNA isolation and purification.
Biochemical Research
As a polyamine, spermine tetrahydrochloride plays a role in various cellular processes. It is used in research settings to study DNA-protein interactions, gene expression, and cell growth.
Cell Biology Studies
This compound can be utilised in cell culture and studies investigating cellular functions, including its effects on cell proliferation and signalling pathways.
| Molecular weight | 348.18 |
|---|---|
| Empirical formula | C10H26N4 · 4HCl |
| Assay | ≥99.5% (AT) |
| Form | powder |
| Density | 1.01 g/mL at 20 °C |
| Solubility | water, high purity: soluble100 mg/ml |
| pH | 4.5-7.0 (25 °C, 1 M in H2O) |
| Melting point | 310-311 °C (dec.)(lit.) |
| Storage temperature | room temp |
| Impurities tested | DNases, none detectedRNases, none detectedinsoluble matter, passes filter testphosphatases, none detectedproteases, none detected |
| Application | Used to precipitate DNA from low salt aqueous buffers.4 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/38 |
| Safety statements (S) | 26-36 |
| Anion traces | sulfate (SO42-): ≤50 mg/kg |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... GRIN1(2902) |
|---|---|
| Uv Absorption | λ: 260 nm Amax: 0.2λ: 280 nm Amax: 0.15 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Spermine tetrahydrochloride used for?
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Spermine tetrahydrochloride is primarily used to precipitate DNA from low salt aqueous buffers and in various biochemical and cell biology research applications.
What is the CAS number and formula for Spermine tetrahydrochloride?
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The CAS number is 306-67-2 and the empirical formula is C10H26N4 · 4HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Spermine tetrahydrochloride with a purity of ≥99.5% (AT). We do not represent this product as USP, BP, or EP grade.
How should Spermine tetrahydrochloride be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves. It is classified as a skin and eye irritant (H315, H319).
Is Spermine tetrahydrochloride a controlled substance?
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The provided data does not indicate that Spermine tetrahydrochloride is a controlled substance.
How is Spermine tetrahydrochloride packed and shipped?
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Spermine tetrahydrochloride is typically supplied as a powder and exported globally by Tech Serve Solutions.
How can I request a quote or sample?
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Please contact our sales team or use the online enquiry form on the Tech Serve Solutions website to request a quote or sample.
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