Spiperone

CAS 749-02-0C23H26FN3O2Biochemicals & Reagents

Spiperone (CAS: 749-02-0), with the molecular formula C23H26FN3O2 and a molecular weight of 395.47, is a light yellow solid. This compound functions as a potent antagonist, primarily utilised in neuroscientific research for its activity on dopamine receptors. It serves as a valuable tool in understanding neurotransmission and related biological pathways. Tech Serve Solutions supplies Spiperone for research and development purposes.

IUPAC: 8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one,R 5147,Spiroperidol
Synonyms: SpiroperidolR 51478-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

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Spiperone (C23H26FN3O2) — chemical structure, CAS 749-02-0; Life Science, fine chemical supplied by Tech Serve Solutions

AntagonistsBioactive Small MoleculesBiochemicals and ReagentsCell BiologyDopaminargics - AntagonistsDopaminergicsGPCR ModulatorsGPCR ProteinsModulators and AntibodiesNeuroscience

01 /Applications

Dopamine Receptor Research

Spiperone has been employed in studies investigating the role of dopamine receptors in physiological processes. For instance, it was used to explore the function of dopamine receptors in mediating male sexual behaviour in avian models.

Neuroscience and Cell Signaling

As a dopaminergic antagonist, Spiperone is a key reagent for researchers in neuroscience. It aids in the study of neurotransmission, cell signaling pathways, and the function of G protein-coupled receptors (GPCRs) within the central nervous system.

Biochemical Research Tool

This compound serves as a biochemical tool for in vitro and in vivo studies. Its specific interactions with dopamine receptors make it useful for characterising receptor function and developing new therapeutic strategies.

02 /Properties

Molecular weight	395.47
Empirical formula	C23H26FN3O2
Form	solid
Colour	light yellow
Solubility	H2O: slightly soluble0.2 mg/mL0.1 M HCl: slightly soluble0.3 mg/mLethanol: soluble1.5 mg/mL45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2 mg/mL
Application	Spiperone was used to study the role of dopamine receptors in facilitating the male sexual behavior in quails.6

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Warning

Hazard statements

H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child

Precautionary statements

P281Use personal protective equipment as required

Protective equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	63-22
Safety statements (S)	36/37

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

749-02-0

MDL number

MFCD00055099

PubChem substance

24277908

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Spiperone used for?

Spiperone is primarily used in neuroscience research as a dopamine receptor antagonist. It aids in the study of neurotransmission, cell signaling, and dopamine receptor function, including its role in behaviours.

What is the CAS number and formula for Spiperone?

The CAS number for Spiperone is 749-02-0, and its molecular formula is C23H26FN3O2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Spiperone as a research-grade chemical. The exact purity and assay information are available on the product's Certificate of Analysis. TSS does not represent this product as USP, BP, or EP grade.

How should Spiperone be handled safely?

Spiperone is classified as harmful if swallowed (H302) and suspected of damaging fertility or the unborn child (H361). Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator (N100/P3), should be used. Handle in a well-ventilated area.

Is Spiperone a controlled substance?

The provided data does not indicate that Spiperone is a controlled substance. However, researchers should always comply with local regulations.

How is Spiperone shipped and exported?

Spiperone is exported as a solid chemical. Packaging and shipping comply with international regulations for chemical transport. Please contact TSS for specific export inquiries.