Combretastatin A4
Combretastatin A4 (CAS: 117048-59-6), with the molecular formula C18H20O5 and a molecular weight of 316.35 g/mol, is supplied as an off-white powder. This compound is recognised for its biological activity, particularly in research settings related to cell cycle and signaling pathways. It is commonly used as a tool compound in apoptosis studies and as a reference standard in biochemical research.
- IUPAC
- 1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene,2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,CA4
- Synonyms
- CA42-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene
Research into Apoptosis
Combretastatin A4 is frequently utilised in cell biology research to investigate the mechanisms of apoptosis (programmed cell death). Its known effects make it a valuable probe for understanding cellular regulatory pathways.
Cell Cycle Analysis
This compound serves as a research chemical for studies focusing on cell cycle progression and related molecular events. Researchers employ it to explore how cellular division is regulated and influenced by external agents.
Biochemical Studies
As a bioactive small molecule, Combretastatin A4 is used in various biochemical assays and studies. Its specific properties allow for its application in exploring molecular interactions within cellular systems.
| Molecular weight | 316.35 |
|---|---|
| Empirical formula | C18H20O5 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | off-white |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | −20°C |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H318Causes serious eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1/PG 3 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25-41 |
| Safety statements (S) | 26-36/37-39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Combretastatin A4 primarily used for?
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Combretastatin A4 (CAS: 117048-59-6) is primarily used as a research chemical in studies investigating apoptosis, cell cycle regulation, and other cellular processes. It is supplied by Tech Serve Solutions for laboratory and research purposes.
What is the CAS number and molecular formula for Combretastatin A4?
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The CAS number for Combretastatin A4 is 117048-59-6, and its molecular formula is C18H20O5.
What grade and purity does Tech Serve Solutions supply for Combretastatin A4?
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Tech Serve Solutions supplies Combretastatin A4 with an assay of ≥98% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or other pharmacopoeial grades.
What are the safety considerations when handling Combretastatin A4?
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Combretastatin A4 is classified with Danger signal word and carries hazard statements H301 (Toxic if swallowed), H311 (Toxic in contact with skin), H318 (Causes serious eye damage), and H331 (Toxic if inhaled). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges, is essential. Handle with extreme caution in a well-ventilated area or fume hood.
How is Combretastatin A4 typically packed and shipped?
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Combretastatin A4 is typically supplied as an off-white powder and stored at -20°C. It is packed securely for export by Tech Serve Solutions, adhering to relevant shipping regulations for chemical compounds.
How can I request a quote or sample for Combretastatin A4?
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To request a quote or a sample of Combretastatin A4, please contact the Tech Serve Solutions sales department via our website or direct inquiry channels, providing your specific research requirements.
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