Staurosporine from Streptomyces sp.
Staurosporine, derived from *Streptomyces sp.* (CAS: 62996-74-1), is a potent protein kinase inhibitor with the molecular formula C28H26N4O3 and a molecular weight of 466.53. This compound is widely utilised in biochemical research for its ability to induce programmed cell death and as a tool in cell signalling studies. It is supplied by Tech Serve Solutions as a high-quality PREMIUM grade material.
- IUPAC
- Antibiotic AM-2282
Protein Kinase Inhibition Studies
Staurosporine is a broad-spectrum protein kinase inhibitor, frequently employed in research to investigate the roles of various kinases in cellular processes, including cell proliferation, differentiation, and apoptosis.
Induction of Apoptosis
This compound has been used to induce programmed cell death (apoptosis) in various cell lines, including human mesenchymal stem cells and hamster lung fibroblasts, making it a valuable reagent for cell death research.
Cell Signalling Research
As a tool to probe cellular signalling pathways, Staurosporine is applied in studies investigating the effects of kinase inhibition on complex cellular events and regulatory mechanisms.
| Molecular weight | 466.53 |
|---|---|
| Empirical formula | C28H26N4O3 |
| Assay | ≥95% (HPLC) |
| Form | film |
| Solubility | DMSO: solubleH2O: insolubleethanol: solublemethanol: soluble |
| Storage temperature | 2-8°C |
| Application | Staurosporine from Streptomyces sp. was used to induce cell death in human mesenchymal stem cells1 and to induce cell death by PKC inhibition in hamster lung fibroblast line CCL-39.2 |
Hazard statements
- H340May cause genetic defects
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P308IF exposed or concerned
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-46 |
| Safety statements (S) | 53-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Staurosporine from Streptomyces sp. used for?
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Staurosporine from *Streptomyces sp.* is primarily used in research as a protein kinase inhibitor to study cellular signalling pathways and to induce apoptosis (programmed cell death) in various cell types.
What are the CAS number and formula for Staurosporine?
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The CAS number for Staurosporine is 62996-74-1, and its empirical formula (Hill notation) is C28H26N4O3.
What grade and purity does Tech Serve Solutions supply for Staurosporine?
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Tech Serve Solutions supplies Staurosporine at a PREMIUM quality level with an assay of ≥95% (HPLC).
How should Staurosporine be handled safely?
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Staurosporine is classified as a Category 1 Mutagen (H340) and Category 1 Carcinogen (H350), indicated by the GHS08 symbol and 'Danger' signal word. Handle with extreme caution, using appropriate personal protective equipment including eyeshields, gloves, and respiratory protection (e.g., N100 respirator). Avoid exposure and ensure adequate ventilation. Store at 2-8°C.
How is Staurosporine packed and shipped?
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Staurosporine is supplied in film form and is stored at 2-8°C. It is packaged to ensure stability during transit and is available for export globally by Tech Serve Solutions.
How can I request a quote or sample for Staurosporine?
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To request a quote or a sample of Staurosporine, please contact Tech Serve Solutions directly through our website or sales department.
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