(S)-Ethyl piperidine-3-carboxylate
(S)-Ethyl piperidine-3-carboxylate (CAS: 37675-186, C8H15NO2, MW: 157.21) is a chiral building block used in chemical synthesis. This enantiomerically pure compound serves as a key intermediate in the development of various pharmaceuticals, including DPP-4 inhibitors, JAK2 inhibitors, and serotonin-noradrenaline reuptake inhibitors. Its reactive nature also facilitates direct C-H functionalization in heterocyclic compounds, making it a versatile tool for organic chemists.
- IUPAC
- (S)-Ethyl nipecotate,(S)-3-Piperidinecarboxylic acid ethyl ester
- Synonyms
- (S)-Ethyl nipecotate(S)-3-Piperidinecarboxylic acid ethyl ester
Pharmaceutical Intermediate
Utilised as a crucial reactant in the synthesis of advanced pharmaceutical compounds such as DPP-4 inhibitors, JAK2 inhibitors, and serotonin and noradrenaline reuptake inhibitors.
Heterocyclic Compound Functionalization
Enables direct C-H functionalization of free (NH)-heterocycles through oxidative arylation, offering a reactive pathway for structural modification.
Chiral Synthesis
Serves as a valuable chiral building block in asymmetric synthesis, contributing to the stereoselective construction of complex molecules.
| Molecular weight | 157.21 |
|---|---|
| Empirical formula | C8H15NO2 |
| Assay | 97% |
| Density | 1.043 g/mL at 25 °C |
| Refractive index | n20/D 1.471 |
| Application | Reactant for synthesis of:• DPP-4 inhibitors1• JAK2 inhibitors2• Serotonin and noradrenaline reuptake inhibitors3• Human tryptase inhibitors4• Anti-thrombotic nicecotamides5Reactive for oxidative C-arylation of free (NH)-heterocycles via direct (sp3) C-H bond functionalization6 |
Hazard statements
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 76 °C / 168.8 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-Ethyl piperidine-3-carboxylate used for?
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(S)-Ethyl piperidine-3-carboxylate is used as a reactant in the synthesis of various pharmaceuticals, including DPP-4 inhibitors, JAK2 inhibitors, and serotonin and noradrenaline reuptake inhibitors. It is also reactive for oxidative C-arylation of free (NH)-heterocycles via direct (sp3) C-H bond functionalization.
What are the CAS number and formula for (S)-Ethyl piperidine-3-carboxylate?
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The CAS number is 37675-186 and the empirical formula is C8H15NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (S)-Ethyl piperidine-3-carboxylate with a minimum assay of 97%. This product is intended for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or any other pharmacopoeial grade.
How should (S)-Ethyl piperidine-3-carboxylate be handled safely?
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(S)-Ethyl piperidine-3-carboxylate is classified as a Danger hazard (GHS05) and carries the hazard statement H318 (Causes serious eye damage). Appropriate personal protective equipment, including eyeshields and suitable gloves, must be worn. Full-face respirators or specific respirator filters (type ABEK) are recommended for protection. Handle in accordance with all applicable safety regulations.
Can Tech Serve Solutions export (S)-Ethyl piperidine-3-carboxylate?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, and can fulfil export orders for (S)-Ethyl piperidine-3-carboxylate.
How can I request a sample or quote for (S)-Ethyl piperidine-3-carboxylate?
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To request a sample or a quotation for (S)-Ethyl piperidine-3-carboxylate, please contact our sales team through the website or by phone, providing your specific requirements.
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