(S)-C3-TunePhos

CAS 486429-99-6C39H32O2P2Chemical Synthesis

(S)-C3-TunePhos, CAS 486429-99-6, is a sophisticated chiral phosphine ligand with the molecular formula C39H32O2P2 and a molecular weight of 594.62 g/mol. It is widely recognised for its efficacy in asymmetric synthesis, particularly in ruthenium-catalyzed asymmetric hydrogenations. This ligand offers comparable or superior enantioselectivities to BINAP in key synthetic transformations, making it an invaluable tool for the precise construction of chiral molecules.

IUPAC: (S)-Bis(diphenylphosphino)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonin

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(S)-C3-TunePhos (C39H32O2P2) — chemical structure, CAS 486429-99-6; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisChemical SynthesisChiral CatalystsLigandsand Reagents

01 /Applications

Asymmetric Hydrogenation of β-Keto Esters

(S)-C3-TunePhos, when used as a ligand in ruthenium catalysts, provides high enantioselectivity in the asymmetric hydrogenation of β-keto esters, a crucial step in synthesising chiral intermediates.

Hydrogenation of Cyclic β-(Acylamino)acrylates

This ligand demonstrates significant utility in the Ru-catalyzed asymmetric hydrogenation of cyclic β-(acylamino)acrylates, leading to enantiomerically enriched products essential for pharmaceutical synthesis.

Asymmetric Hydrogenation of α-Phthalimide Ketones

It enables efficient asymmetric hydrogenation of α-phthalimide ketones, contributing to the development of stereoselective synthetic routes for complex chiral molecules.

02 /Properties

Molecular weight	594.62
Empirical formula	C39H32O2P2
Application	Provides comparable or superior enantioselectivities and catalytic abilities to BINAP in Ru-catalyzed asymmetric hydrogenations of β-keto esters5, cyclic β-(acylamino)acrylates6 and a-phthalimide ketones7.

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

486429-99-6

MDL number

MFCD06658115

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (S)-C3-TunePhos used for?

(S)-C3-TunePhos is primarily used as a chiral ligand in ruthenium-catalyzed asymmetric hydrogenation reactions, offering high enantioselectivity and catalytic efficiency for substrates such as β-keto esters, cyclic β-(acylamino)acrylates, and α-phthalimide ketones.

What is the CAS number and molecular formula for (S)-C3-TunePhos?

The CAS number for (S)-C3-TunePhos is 486429-99-6, and its molecular formula is C39H32O2P2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies (S)-C3-TunePhos as a research-grade chemical. We do not represent it as USP, BP, EP, or any other pharmacopoeia grade.

How should (S)-C3-TunePhos be handled safely?

Handle (S)-C3-TunePhos with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It is classified under WGK Germany 3, indicating a hazard to water.

How is (S)-C3-TunePhos packed and shipped?

Tech Serve Solutions carefully packs and ships fine chemicals globally, adhering to all necessary regulations for international transport.

How can I request a sample or quote for (S)-C3-TunePhos?

To request a sample or quote for (S)-C3-TunePhos, please contact our sales team through the website or by phone, providing your specific requirements.