(S)-(−)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane
(S)-(−)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane (CAS 60456-22-6) is a chiral building block with the molecular formula C6H11ClO2 and a molecular weight of 150.60 g/mol. This protected alcohol is vital in asymmetric synthesis and general chemical synthesis. Its specific stereochemistry makes it an invaluable intermediate for the stereoselective construction of complex organic molecules, finding utility in pharmaceutical research and development.
- Synonyms
- 60456-22-6C6H11ClO2
Chiral Intermediate in Pharmaceutical Synthesis
This enantiomerically pure compound serves as a key chiral building block for synthesizing complex active pharmaceutical ingredients (APIs) where specific stereochemistry is critical for efficacy and safety.
Asymmetric Synthesis
Utilised in stereoselective reactions to introduce chirality into target molecules, facilitating the creation of optically active compounds. Its dioxolane protecting group is stable under various conditions.
Organic Building Block
Acts as a versatile precursor in organic synthesis, enabling the construction of diverse molecular architectures due to the reactive chloromethyl moiety and the protected diol functionality.
| Molecular weight | 150.60 |
|---|---|
| Empirical formula | C6H11ClO2 |
| Assay | 98% |
| Boiling point | 63 °C/37 mmHg(lit.) |
| Density | 1.103 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.434(lit.) |
| Optical activity | [α]24/D −42.1°, neat |
Hazard statements
- H226Flammable liquid and vapour
- H301Toxic if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 51 °C / 123.8 °F |
| Transport (UN / ADR) | UN 1993 3/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 10-25-41 |
| Safety statements (S) | 16-26-36/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(−)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane used for?
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It is primarily used as a chiral building block in asymmetric synthesis and for constructing complex organic molecules, particularly in the pharmaceutical industry.
What are the CAS number and formula for this chemical?
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The CAS number is 60456-22-6, and the empirical formula (Hill notation) is C6H11ClO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with a minimum assay of 98%. This is a technical grade, and TSS does not represent it as USP, BP, or EP.
How should (S)-(−)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane be handled?
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This compound is a flammable liquid and solid, causes severe eye damage, and is toxic if swallowed. Handle with appropriate personal protective equipment including eyeshields, face shields, gloves, and a suitable respirator. Ensure adequate ventilation and avoid ignition sources.
Is this chemical a controlled substance?
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The provided data does not indicate that this chemical is a controlled substance.
How is (S)-(−)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane packed and shipped?
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As a global supplier and exporter, Tech Serve Solutions ensures secure and compliant packaging for international shipments, adhering to all relevant transport regulations for hazardous materials like UN 1993.
How can I request a sample or quote?
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Please contact our sales team via the website or direct email to request a sample or obtain a quotation for (S)-(−)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane.
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