(S)-(+)-1-(1-Naphthyl)ethyl isocyanate
(S)-(+)-1-(1-Naphthyl)ethyl isocyanate (CAS: 73671-79-1), with the molecular formula C₁₀H₇CH(CH₃)NCO and a molecular weight of 197.23 g/mol, is a chiral isocyanate. This compound is primarily utilised as a derivatization reagent in analytical chemistry, particularly for the chiral resolution and characterisation of alcohols and amines via HPLC. Its ability to form stable derivatives makes it valuable in asymmetric synthesis and as a building block in organic chemistry.
- IUPAC
- (S)-NEI
- Synonyms
- (S)-NEI
Chiral Derivatization Reagent
(S)-(+)-1-(1-Naphthyl)ethyl isocyanate is employed to derivatise chiral alcohols and amines. This process facilitates the chromatographic separation and identification of enantiomers, offering precise analytical results.
Asymmetric Synthesis
As a chiral building block, this isocyanate can be incorporated into synthetic routes requiring stereospecificity. It enables the construction of complex chiral molecules for pharmaceutical and materials science applications.
Analytical/Chromatography Applications
Its reactivity with functional groups makes it a useful reagent for enhancing the detectability and separability of analytes in chromatographic techniques, including HPLC.
| Molecular weight | 197.23 |
|---|---|
| Linear formula | C10H7CH(CH3)NCO |
| Assay | 99% |
| Boiling point | 106-108 °C/0.16 mmHg(lit.) |
| Density | 1.128 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.604(lit.) |
| Optical activity | [α]20/D +45°, c = 3.5 in toluene |
| Optical purity | ee: 96% (GLC) |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P342
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 93 °C / 199.4 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 36/37/38-42/43 |
| Safety statements (S) | 23-26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality | stabilized |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(+)-1-(1-Naphthyl)ethyl isocyanate used for?
+
(S)-(+)-1-(1-Naphthyl)ethyl isocyanate is primarily used as a chiral derivatization reagent for the analysis and separation of enantiomers, particularly alcohols and amines, in chromatography. It also serves as a building block in asymmetric synthesis.
What is the CAS number and molecular formula for (S)-(+)-1-(1-Naphthyl)ethyl isocyanate?
+
The CAS number is 73671-79-1 and the molecular formula is C₁₀H₇CH(CH₃)NCO.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies (S)-(+)-1-(1-Naphthyl)ethyl isocyanate with an assay of 99%. This product is stabilised. Tech Serve Solutions does not represent this product as USP, BP, or EP grade.
How should (S)-(+)-1-(1-Naphthyl)ethyl isocyanate be handled safely?
+
This compound is classified as a Danger. It causes skin irritation (H315), may cause an allergic skin reaction (H317), causes serious eye irritation (H319), and may cause allergy or asthma symptoms or breathing difficulties if inhaled (H334). Use in a well-ventilated area or with appropriate respiratory protection. Wear protective gloves, eye protection, and face protection. Store at 2-8°C.
How is this chemical packed, shipped, or exported?
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As a global supplier, Tech Serve Solutions expertly packages and exports chemicals worldwide, adhering to all relevant shipping regulations for hazardous materials like UN 2206, Class 6.1, Packing Group III.
How can I request a sample or quote for (S)-(+)-1-(1-Naphthyl)ethyl isocyanate?
+
To request a sample or a quote, please contact our sales team via the website or provide your details through the online enquiry form.
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