(R)-VAPOL
(R)-VAPOL (CAS: 147702-16-7), a BINOL derivative with the molecular formula C40H26O2 and a molecular weight of 538.63 g/mol, is a privileged chiral ligand. It is widely recognised for its efficacy in various asymmetric catalytic reactions, including Diels-Alder, imine aldol, and aziridination processes. Its unique structure and properties make it a valuable tool for stereoselective synthesis in academic research and industrial applications.
- IUPAC
- (R)-2,2′-Diphenyl-3,3′-(4-biphenanthrol)
Asymmetric Diels-Alder Reactions
(R)-VAPOL serves as an effective chiral ligand in catalysing asymmetric Diels-Alder reactions, facilitating the stereoselective formation of cyclic compounds.
Imine Aldol Reactions
This compound has demonstrated excellent performance as a ligand in asymmetric imine aldol reactions, enabling enantioselective carbon-carbon bond formation.
Aziridination Reactions
The ligand is utilised in catalysing asymmetric aziridination reactions, providing access to chiral aziridines with high stereocontrol.
Chiral Ligand for Catalysis
(R)-VAPOL is a key component in the development of chiral catalysts for a range of asymmetric transformations, promoting high enantioselectivity and efficiency.
| Molecular weight | 538.63 |
|---|---|
| Empirical formula | C40H26O2 |
| Assay | 97% |
| Optical activity | [α]20/D -144°, c = 1 in chloroform |
| Application | VAPOL has proven to be an excellent ligand in catalytic asymmetric Diels-Alder, imine aldol, and aziridination reactions.1,2,3 |
| Melting point | 225-229 °C |
Hazard statements
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 37/38-40-41 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-VAPOL used for?
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(R)-VAPOL is primarily used as a chiral ligand in asymmetric synthesis, particularly in Diels-Alder, imine aldol, and aziridination reactions.
What is the CAS number and chemical formula for (R)-VAPOL?
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The CAS number for (R)-VAPOL is 147702-16-7 and its empirical formula is C40H26O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-VAPOL with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should (R)-VAPOL be handled safely?
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Handle (R)-VAPOL with care. It is classified as causing skin irritation (H315), serious eye damage (H318), and may cause respiratory irritation (H335). It is also suspected of causing cancer (H351). Always wear appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, and ensure adequate ventilation.
How is (R)-VAPOL packed, shipped, and exported?
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(R)-VAPOL is carefully packed to ensure integrity during transit. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, adhering to all necessary regulations for international shipment.
How can I request a sample or quote for (R)-VAPOL?
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To request a sample or a quotation for (R)-VAPOL, please contact our sales team through the website or by phone, providing your specific requirements.
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