4-(Trifluoromethyl)benzoic acid
4-(Trifluoromethyl)benzoic acid (CAS 455-24-3), with the molecular formula CF3C6H4CO2H and a molar mass of 190.12 g/mol, is a versatile organic compound. It is a key building block and carboxylic acid derivative utilised in various chemical syntheses. Its notable applications include its use in the development of salicylanilide derivatives and as an internal standard for analytical methods involving fluorinated aromatic carboxylic acids. Available at a purity of 98%.
- IUPAC
- α,α,α-Trifluoro-p-toluic acid,4-Carboxybenzotrifluoride
- Synonyms
- α,α,α-Trifluoro-p-toluic acid4-Carboxybenzotrifluoride
Synthesis of Salicylanilide Derivatives
4-(Trifluoromethyl)benzoic acid has been employed in the synthesis of salicylanilide 4-(trifluoromethyl)benzoates through N,N′-dicyclohexylcarbodiimide coupling reactions in anhydrous N,N-dimethylformamide.
Analytical Internal Standard
This compound serves as an effective internal standard for the ultra-trace analysis of fluorinated aromatic carboxylic acids using gas chromatography/mass spectrometry (GC/MS) methodologies.
Organic Synthesis Building Block
As a carboxylic acid featuring a trifluoromethyl group, it functions as a valuable building block in organic synthesis for introducing the trifluoromethylphenyl moiety into target molecules.
| Molecular weight | 190.12 |
|---|---|
| Linear formula | CF3C6H4CO2H |
| Assay | 98% |
| Application | 4-(Trifluoromethyl)benzoic acid was used in the synthesis of salicylanilide 4-(trifluoromethyl)benzoates via N,N′-dicyclohexylcarbodiimide coupling in dry N,N-dimethylformamide1. It was used as internal standard during the ultra trace analysis of fluorinated aromatic carboxylic acids by GC/MS method2. |
| Melting point | 219-220 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethyl)benzoic acid used for?
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4-(Trifluoromethyl)benzoic acid is used as a building block in organic synthesis, particularly in the preparation of salicylanilide derivatives and as an internal standard in analytical chemistry for the detection of fluorinated aromatic carboxylic acids.
What is the CAS number and molecular formula for 4-(Trifluoromethyl)benzoic acid?
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The CAS number is 455-24-3 and the molecular formula is CF3C6H4CO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Trifluoromethyl)benzoic acid with an assay of 98%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should 4-(Trifluoromethyl)benzoic acid be handled?
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Warning: Causes skin irritation, serious eye irritation, and may cause respiratory irritation. Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure good ventilation and avoid breathing dust. P261, P305 + P351 + P338.
Is 4-(Trifluoromethyl)benzoic acid a controlled substance?
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The provided data does not indicate that 4-(Trifluoromethyl)benzoic acid is a controlled substance.
How is 4-(Trifluoromethyl)benzoic acid packed and exported?
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Tech Serve Solutions exports fine chemicals globally, adhering to all necessary regulations for safe and compliant packaging and shipping.
How can I request a sample or quote for 4-(Trifluoromethyl)benzoic acid?
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To request a sample or a quote, please contact our sales department via the details provided on our website.
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