4-(Trifluoromethyl)benzyl bromide
4-(Trifluoromethyl)benzyl bromide (CAS: 402-49-3; Formula: CF3C6H4CH2Br; Molar Mass: 239.03 g/mol) is a halogenated organic compound. It serves as a versatile building block in chemical synthesis. Its reactive benzylic bromide functional group, adjacent to an electron-withdrawing trifluoromethyl-substituted phenyl ring, makes it valuable for introducing the 4-(trifluoromethyl)benzyl moiety into various organic molecules. This compound is primarily used in research and development for the synthesis of complex organic structures.
- IUPAC
- α′-Bromo-α,α,α-trifluoro-p-xylene,4-(Bromomethyl)benzotrifluoride
- Synonyms
- 4-(Bromomethyl)benzotrifluorideα′-Bromo-α,α,α-trifluoro-p-xylene
Organic Synthesis Intermediate
4-(Trifluoromethyl)benzyl bromide is widely employed as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. Its reactivity allows for facile alkylation reactions, enabling the construction of carbon-carbon and carbon-heteroatom bonds.
Reagent for Functionalization
This compound acts as a key reagent for introducing the 4-(trifluoromethyl)benzyl group into target molecules. This fluorinated moiety can impart desirable properties such as increased lipophilicity and metabolic stability to the final product.
Research and Development
In academic and industrial research laboratories, 4-(Trifluoromethyl)benzyl bromide is utilized for exploring novel synthetic pathways and developing new chemical entities with specific biological or material properties.
| Molecular weight | 239.03 |
|---|---|
| Linear formula | CF3C6H4CH2Br |
| Assay | 98% |
| Boiling point | 65-69 °C/5 mmHg(lit.) |
| Density | 1.546 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.484(lit.) |
| Melting point | 29-33 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethyl)benzyl bromide used for?
+
4-(Trifluoromethyl)benzyl bromide is primarily used as a versatile building block and intermediate in organic synthesis for creating complex molecules, including pharmaceuticals, agrochemicals, and research compounds. It facilitates the introduction of the 4-(trifluoromethyl)benzyl group.
What are the CAS number and chemical formula for 4-(Trifluoromethyl)benzyl bromide?
+
The CAS number for 4-(Trifluoromethyl)benzyl bromide is 402-49-3, and its chemical formula is CF3C6H4CH2Br.
What grade and purity does Tech Serve Solutions supply for 4-(Trifluoromethyl)benzyl bromide?
+
Tech Serve Solutions supplies 4-(Trifluoromethyl)benzyl bromide with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 4-(Trifluoromethyl)benzyl bromide be handled safely?
+
4-(Trifluoromethyl)benzyl bromide is classified as Danger with hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection (type N100 or P3 filters), must be used. Handle in a well-ventilated area and follow safety guidelines strictly.
Does Tech Serve Solutions export 4-(Trifluoromethyl)benzyl bromide?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-(Trifluoromethyl)benzyl bromide, and can accommodate international shipping requirements.
How can I request a sample or quote for 4-(Trifluoromethyl)benzyl bromide?
+
To request a sample or obtain a quotation for 4-(Trifluoromethyl)benzyl bromide, please contact our sales team through the provided channels on our website.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis