(R)-(+)-Glycidyl trityl ether
(R)-(+)-Glycidyl trityl ether (CAS: 65291-30-7, C22H20O2) is a chiral epoxide with a molecular weight of 316.39. It serves as a valuable building block in asymmetric synthesis. This compound is primarily utilized in the preparation of various biologically relevant molecules, including nucleoside analogs and modified phospholipids, through stereoselective ring-opening reactions.
Synthesis of Nucleoside Analogs
This chiral epoxide is employed in the synthesis of nucleotides with potential activity against herpes simplex virus (HSV-1 and HSV-2). Ring-opening reactions with cytosine derivatives yield modified nucleosides.
Preparation of Modified Lipids
The epoxide can be reacted with amines to create novel lipid ammonium salts. Furthermore, it is used in the synthesis of thio analogs of phospholipids via reaction with thiols.
Chiral Building Block
As an enantiomerically pure epoxide, (R)-(+)-Glycidyl trityl ether is a key intermediate in asymmetric synthesis, enabling the construction of complex chiral molecules with defined stereochemistry.
| Molecular weight | 316.39 |
|---|---|
| Empirical formula | C22H20O2 |
| Assay | 98% |
| Optical activity | [α]20/D +10.5°, c = 1 in chloroform |
| Optical purity | ee: 98% (GLC) |
| Application | Nucleotides with activity against herpes simplex virus 1 and 2, lipid ammonium salts, and thio analogs of phospholipids have been prepared recently through ring-opening of this epoxide with cytosine derivatives,1 amines,2 and thiols,3 respectively. |
| Melting point | 99-102 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-Glycidyl trityl ether used for?
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(R)-(+)-Glycidyl trityl ether is used as a chiral building block in asymmetric synthesis, particularly for the preparation of nucleoside analogs and modified lipids, including thio analogs of phospholipids and lipid ammonium salts.
What are the CAS number and chemical formula for (R)-(+)-Glycidyl trityl ether?
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The CAS number for (R)-(+)-Glycidyl trityl ether is 65291-30-7, and its chemical formula is C22H20O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(+)-Glycidyl trityl ether with an assay of 98% and an optical purity of 98% ee (GLC). This is a research grade material and is not supplied as USP, BP, or EP.
How should (R)-(+)-Glycidyl trityl ether be handled safely?
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Handling of (R)-(+)-Glycidyl trityl ether requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Consult the Safety Data Sheet for full handling instructions.
Is (R)-(+)-Glycidyl trityl ether subject to any special regulations?
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No, the provided data does not indicate that (R)-(+)-Glycidyl trityl ether is a controlled substance. However, it is classified with WGK 3 in Germany.
How is (R)-(+)-Glycidyl trityl ether packed, shipped, and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packaging and shipping protocols are followed for all chemicals, including (R)-(+)-Glycidyl trityl ether, in compliance with international regulations.
How can I request a sample or quote for (R)-(+)-Glycidyl trityl ether?
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To request a sample or a quote for (R)-(+)-Glycidyl trityl ether, please contact our sales team through the website or by phone, providing the product name and CAS number.
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