Diethyl malonate
Diethyl malonate (CAS 105-53-3), with the molecular formula CH2(COOC2H5)2 and a molar mass of 160.17 g/mol, is a versatile organic ester. It is commonly employed as a key building block in chemical synthesis, particularly for the production of pharmaceuticals, fragrances, and flavourings. Its reactive methylene group allows for facile alkylation and condensation reactions, making it indispensable in various organic transformations.
- IUPAC
- Malonic acid diethyl ester
- Synonyms
- Malonic acid diethyl esterDiethyl ester of malonic acidMalonic acid, diethyl esterDiethyl ester malonate
Pharmaceutical Intermediate
Diethyl malonate serves as a crucial starting material or intermediate in the synthesis of a wide range of active pharmaceutical ingredients (APIs). It is integral to the construction of complex molecular scaffolds found in various drug classes.
Fragrance and Flavour Synthesis
This ester is utilised in the creation of synthetic fragrances and flavour compounds. Its ability to undergo condensation reactions allows for the formation of various lactones and other molecules contributing to desirable sensory properties.
Organic Synthesis Reagent
As a C3 building block, diethyl malonate is widely used in academic and industrial organic synthesis laboratories. It facilitates the introduction of malonate functionalities into organic molecules through alkylation, acylation, and Michael addition reactions.
Polymer and Material Science
Diethyl malonate can be incorporated into the synthesis of specialty polymers and materials. Its ester functionalities can participate in polymerisation reactions or be modified to impart specific properties to the final material.
| Molecular weight | 160.17 |
|---|---|
| Linear formula | CH2(COOC2H5)2 |
| Assay | ≥99.0% (GC) |
| Grade | puriss. |
| Boiling point | 199 °C(lit.) |
| Density | 1.055 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.413(lit.)n20/D 1.413 |
| Melting point | −51-−50 °C(lit.) |
| Vapour pressure | 1 mmHg (40 °C) |
| Vapour density | 5.52 (vs air) |
Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 90 °C / 194 °F |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl malonate used for?
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Diethyl malonate is primarily used as a versatile building block in organic synthesis for the production of pharmaceuticals, fragrances, flavourings, and various other fine chemicals.
What are the CAS number and formula for Diethyl malonate?
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The CAS number for Diethyl malonate is 105-53-3, and its linear formula is CH2(COOC2H5)2.
What grade and purity does Tech Serve Solutions supply for Diethyl malonate?
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Tech Serve Solutions supplies Diethyl malonate with a minimum assay of ≥99.0% (GC) and a puriss. grade. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Diethyl malonate be handled safely?
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Diethyl malonate is classified with GHS07 and carries a Warning signal word. It causes serious eye irritation (H319). Handle with appropriate personal protective equipment, including eyeshields and gloves. Ensure good ventilation and consult the safety data sheet for full handling instructions.
Is Diethyl malonate a controlled substance?
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Based on the provided data, Diethyl malonate is not indicated as a controlled substance.
How is Diethyl malonate typically packed and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures that Diethyl malonate is packed and handled according to international shipping regulations to maintain product integrity and safety during transit.
How can I request a quote or sample for Diethyl malonate?
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To request a quote or sample for Diethyl malonate, please contact our sales team through the website or by phone, providing your specific requirements.
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