Diethyl methylphosphonate
Diethyl methylphosphonate (CAS: 683-08-9; Formula: CH3P(O)(OC2H5)2; MW: 152.13) is a chemical compound utilised in organic synthesis. It serves as a key reactant in various C-C bond-forming reactions and is particularly valuable in the development of novel phosphonate derivatives. This reagent is integral to olefination processes and is supplied by Tech Serve Solutions for advanced chemical research and synthesis.
- IUPAC
- Bis(diethoxyphosphinyl)methane,DEMP,Diethoxymethylphosphine oxide
Synthesis of Fluoroalkyl Phosphonates
Diethyl methylphosphonate is a reactant in the synthesis of fluoroalkyl α- and β-aminophosphonates. These compounds are of interest in medicinal chemistry due to their potential biological activities.
Development of Antiviral Agents
This compound facilitates the creation of acyclic nucleoside phosphonates with branched phosphonoethoxy-Et chains. These derivatives are being investigated as potential antiviral therapeutics.
Preparation of Difluoromethyl Arylphosphonates
Diethyl methylphosphonate serves as a precursor for the synthesis of difluoromethyl arylphosphonates. This application is relevant in the field of organophosphorus chemistry.
Construction of Heterocyclic Compounds
The reagent is employed in the synthesis of pyridone alkaloids exhibiting neuritogenic activity. It also aids in the construction of the phomactin cyclohexane core and diterpenoid frameworks.
Phosphonylated Peptide Synthesis
Diethyl methylphosphonate is utilised in solid-phase synthesis to create phosphonylated peptides. This method is valuable for creating modified peptide structures for research.
| Molecular weight | 152.13 |
|---|---|
| Linear formula | CH3P(O)(OC2H5)2 |
| Assay | ≥97.0% (GC) |
| Boiling point | 194 °C(lit.) |
| Density | 1.041 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.414(lit.)n20/D 1.414 |
| Application | Reactant for the synthesis of: • Fluoroalkyl α- and β-aminophosphonates1• Acyclic nucleoside phosphonates with branched phosphonoethoxy-Et chains as potential antivirals2• Difluoromethyl arylphosphonates3• Pyridone alkaloids with neuritogenic activity4• Lipophilic meropenem-derived prodrugs5• Phomactin cyclohexane core and diterpenoid framework6• Phosphonylated peptides via solid-phase synthesis7 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 75 °C / 167 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl methylphosphonate (CAS 683-08-9) used for?
+
Diethyl methylphosphonate (CAS: 683-08-9) is used as a reactant in organic synthesis, particularly for C-C bond formation, olefination reactions, and the synthesis of various phosphonate derivatives, including fluoroalkyl and acyclic nucleoside phosphonates.
What are the CAS number and chemical formula for Diethyl methylphosphonate?
+
The CAS number for Diethyl methylphosphonate is 683-08-9, and its chemical formula is CH3P(O)(OC2H5)2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Diethyl methylphosphonate with an assay of ≥97.0% (GC). This is a technical/research grade, and TSS does not represent it as USP, BP, or EP grade.
How should Diethyl methylphosphonate be handled safely?
+
Diethyl methylphosphonate is classified as a warning substance. It can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, should be used. Handle in a well-ventilated area.
Is Diethyl methylphosphonate a controlled substance?
+
The provided data does not indicate that Diethyl methylphosphonate is a controlled substance.
How is Diethyl methylphosphonate packed, shipped, and exported?
+
Tech Serve Solutions exports fine chemicals globally. Specific packing and shipping details for Diethyl methylphosphonate will be provided upon request, adhering to all relevant international shipping regulations.
How can I request a sample or quote for Diethyl methylphosphonate?
+
To request a sample or quote for Diethyl methylphosphonate, please contact our sales team through the website or by phone, referencing the product name and CAS number (683-08-9).
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis