(R)-(+)-Mandelonitrile
(R)-(+)-Mandelonitrile (CAS: 10020-96-9), with the molecular formula C6H5CH(OH)CN and a molar mass of 133.15 g/mol, is a valuable chiral building block. This optically active compound serves as a key intermediate in the synthesis of various optically active organic molecules, including α-hydroxy carboxylic acids, α-hydroxy aldehydes, α-hydroxy ketones, and 2-amino alcohols. Its specific stereochemistry makes it indispensable for creating enantiomerically pure target compounds in fine chemical and pharmaceutical research and development.
- IUPAC
- (R)-(+)-α-Hydroxybenzeneacetonitrile
- Synonyms
- (R)-(+)-α-Hydroxybenzeneacetonitrile
Synthesis of Optically Active α-Hydroxy Acids
(R)-(+)-Mandelonitrile is a crucial precursor for the enantioselective synthesis of optically pure α-hydroxy carboxylic acids. These compounds are important motifs in natural products and pharmaceuticals.
Preparation of Chiral Aldehydes and Ketones
It is employed as a starting material for the preparation of optically active α-hydroxy aldehydes and α-hydroxy ketones. These chiral synthons are valuable in complex organic synthesis.
Access to 2-Amino Alcohols
The compound facilitates the synthesis of chiral 2-amino alcohols, which are prevalent structures in biologically active molecules and ligands for asymmetric catalysis.
Asymmetric Synthesis Intermediate
As a chiral building block, (R)-(+)-Mandelonitrile enables the construction of stereochemically defined molecules, supporting advancements in asymmetric synthesis research.
| Molecular weight | 133.15 |
|---|---|
| Linear formula | C6H5CH(OH)CN |
| Assay | 97% |
| Boiling point | 170 °C(lit.) |
| Density | 1.117 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.532(lit.) |
| Optical activity | [α]20/D +42°, c = 1 in chloroform |
| Melting point | 28-30 °C(lit.) |
| Storage temperature | −20°C |
| Application | Useful intermediate in the preparation of optically active α-hydroxy carboxylic acids, α-hydroxy aldehydes, α-hydroxy ketones, and 2-amino alcohols.1 |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H331Toxic if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25-36/37/38-41 |
| Safety statements (S) | 22-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-Mandelonitrile used for?
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Tech Serve Solutions supplies (R)-(+)-Mandelonitrile primarily as an intermediate for the synthesis of optically active α-hydroxy carboxylic acids, α-hydroxy aldehydes, α-hydroxy ketones, and 2-amino alcohols, crucial for asymmetric synthesis.
What is the CAS number and chemical formula for (R)-(+)-Mandelonitrile?
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The CAS number for (R)-(+)-Mandelonitrile is 10020-96-9, and its chemical formula is C6H5CH(OH)CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(+)-Mandelonitrile with an assay of 97%. This product is supplied for research and manufacturing purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should (R)-(+)-Mandelonitrile be handled safely?
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(R)-(+)-Mandelonitrile is classified as Danger. It is toxic if swallowed, in contact with skin, and if inhaled. It also causes skin and serious eye irritation and may cause respiratory irritation. Always use appropriate personal protective equipment, including eyeshields, face shields, gloves, and a P2 respirator cartridge. Handle in a well-ventilated area and avoid exposure.
How is (R)-(+)-Mandelonitrile packed, shipped, and exported?
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As a global supplier, Tech Serve Solutions exports (R)-(+)-Mandelonitrile worldwide, adhering to all relevant shipping and handling regulations for hazardous materials. Specific packaging details are available upon request.
How can I request a sample or quote for (R)-(+)-Mandelonitrile?
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To request a sample or a quote for (R)-(+)-Mandelonitrile, please contact our sales team directly through the Tech Serve Solutions website or by phone.
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