(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(4-methylphenyl)phosphine]
(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(4-methylphenyl)phosphine] (CAS: 133545-24-1) is a chiral phosphine ligand with the molecular formula C42H40O2P2 and a molecular weight of 638.71 g/mol. This atropisomeric ligand, a derivative of MeOBIPHEP, is highly valued for its role in asymmetric synthesis. It is extensively employed as a privileged ligand in various catalytic applications, facilitating the stereoselective formation of complex molecules.
- IUPAC
- (R)-2,2′-Bis(di-p-tolylphosphino)-6,6′-dimethoxy-1,1′-biphenyl,(R)-p-Tol-MeOBIPHEP,SL-A102-1
- Synonyms
- 133545-24-1C42H40O2P2(R)-p-Tol-MeOBIPHEPSL-A102-1(R)-2,2′-Bis(di-p-tolylphosphino)-6,6′-dimethoxy-1,1′-biphenyl
![(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(4-methylphenyl)phosphine] (C42H40O2P2) — chemical structure, CAS 133545-24-1; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F133545-24-1.png&w=3840&q=75)
Asymmetric Catalysis
This compound functions as a key chiral ligand in transition metal-catalyzed asymmetric reactions, enabling the enantioselective synthesis of valuable chiral compounds. It is particularly noted for its utility in reactions such as hydrogenation and C-C bond formation.
Pharmaceutical Intermediate Synthesis
Its ability to control stereochemistry makes it an important reagent in the synthesis of chiral pharmaceutical intermediates. This allows for the efficient production of enantiomerically pure drug precursors.
Fine Chemical Production
In the broader fine chemical industry, this ligand is used to achieve high stereoselectivity in the synthesis of complex organic molecules where specific chirality is critical.
| Molecular weight | 638.71 |
|---|---|
| Empirical formula | C42H40O2P2 |
| Assay | ≥97% |
| Optical purity | ee: ≥99% |
| Application | Atropisomeric MeOBIPHEP ligands |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(4-methylphenyl)phosphine] used for?
+
This compound is primarily used as a chiral ligand in asymmetric catalysis for the synthesis of enantiomerically pure compounds, particularly in the pharmaceutical and fine chemical industries.
What is the CAS number and molecular formula for this chemical?
+
The CAS number is 133545-24-1 and the molecular formula is C42H40O2P2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this chemical with an assay of ≥97% and an optical purity of ee: ≥99%. This is a research-grade chemical and not supplied as USP, BP, EP, or for food/nutraceutical use.
What are the safety and handling precautions for this chemical?
+
This chemical requires the use of eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It is classified with a WGK Germany rating of 3, indicating significant hazard.
How is this chemical shipped and exported?
+
Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and can arrange for the compliant shipping and export of this product worldwide.
How can I request a sample or quote for this product?
+
Please contact our sales team through the website to request a sample or obtain a quotation for this chemical.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis